摘要
目的探讨降钙素原(PCT)、胆碱酯酶(ChE)以及肌钙蛋白I(cCTnI)对分析脓毒症不同程度病情、评估预后的临床实用性。方法选取2012年3月-2015年3月医院收治107例脓毒症患者作为研究对象,根据病情不同程度将其分为脓毒症组45例、严重脓毒症组38例、脓毒症休克组24例,根据入院28d内是否死亡将其分为死亡组22例和存活组85例,分别于入院24h、第3天、第5天检测患者PCT、ChE以及CTnI,比较各组间的指标水平。结果入院时,脓毒症休克组和严重脓毒症组PCT、CTnI显著高于脓毒症组,且脓毒症休克组PCT、CTnI又显著高于严重脓毒症组,差异均有统计学意义(P<0.05);脓毒症休克组和严重脓毒症组ChE显著低于脓毒症组,且脓毒症休克组ChE又显著低于严重脓毒症组,差异均有统计学意义(P<0.05);死亡组各时间点PCT和CTnI水平均显著高于存活组,ChE水平均显著低于存活组,差异有统计学意义(P<0.05)。结论 PCT、ChE以及CTnI可用于分析脓毒症不同程度病情、评估预后,具有较好的临床实用性。
OBJECTIVE To explore the clinical values of procalcitonin （PCT）, cholinesterase （ChE） and troponin I （cCTnI） in the evaluation of septil patients＇ conditions and prognosis. METHODS A total of 107 patients with sep-sis Who had been receiving treatment in our hospital between Mar. 2012 to Mar. 2015 were selected as the re-search objects, who were divided into sepsis group with 45 cases, severe sepsis .group with 38 cases and sepsis shock group with 24 cases, according to their diseases condition. They were divided into death group 22 cases and survive group 85 cases, according to whether dead in 28d after admission to hospital. The PCT, ChE and CTnI of these patients were detected and compared 24 hours, 3 days and 5 days after admission to the hospital for compari- son in different groups. RESULTS On admission, the levels of PCT and CTnI in the septic shock group and severe sepsis group were significantly higher than those in the sepsis group, and the PCT and CTnI in the septic shock group were significantly higher than those in the severe sepsis group. ChE in the septic shock group and the severe sepsis group was significantly lower than that in the sepsis group, and that in the septic shock group was also shown to be significantly lower than that in the severe sepsis group（P〈0.05）. PCT and CTnI in the death group were both significantly higher than those in the survival group at each time point, yet the ChE level was signifi- cantly lower than that in the survival group（P〈0.05）. CONCLUSION PCT, ChE and CTnI can serve as significant indicators in the evaluation of the condition and prognosis of patients with sepsis in clinic.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2016年第20期4621-4623,共3页
Chinese Journal of Nosocomiology
基金
广东省自然科学基金资助项目(05000139)
关键词
降钙素原
胆碱酯酶
肌钙蛋白I
脓毒症
感染
炎症反应综合征
Procalcitonin
Cholinesterase
Cardiac Troponin I
Sepsis
Infection
Inflammatory response syndrome
