摘要
目的 :探讨血清降钙素原(PCT)水平对全身炎症反应综合征(SIRS)患儿病情预后评估的临床意义。方法:采用前瞻性病例对照方法,选取68例确诊的SIRS患儿分为脓毒症组和非脓毒症组,入院后24 h内检测血清PCT水平,作小儿危重病例(PCIS)评分;评估SIRS患儿住院28 d内生存情况,根据患儿临床结局分为死亡组和存活组,采用Spearman法分析患儿血清PCT水平与PCIS评分的关系。结果 :脓毒症组入院时的血清PCT水平明显高于非脓毒症组,而PCIS评分明显低于非脓毒症组患儿(P<0.05);死亡组患儿血清PCT水平明显高于存活组患儿,PCIS评分明显低于存活组患儿(P<0.05);血清PCT水平与PCIS评分呈显著负相关(r=-0.637,P<0.01)。结论 :对SIRS患儿进行血清PCT水平监测,可有助于早期判断脓毒症和非脓毒症,可作为评估SIRS患儿病情预后的重要指标。
Objective：To investigate the clinical signiifcance of serum procalcitonin （PCT） levels in the assessment of the systemic inlfammatory response syndrome （SIRS） in children.Methods： Sixty-eight cases of children with SIRS were selected by a prospective case-control method and divided into a sepsis group and a non-sepsis group based on their exact infection. The levels of serum PCT were detected within 24 h after admission and pediatric critical illness （PCIS） score was performed. The survival of SIRS children in 28 days of hospitalization was assessed and they were divided into a death group and a survival group according to their clinical outcome and the relationship of serum PCT levels with PCIS score was analyzed by Spearman correlation analysis.Results：The serum PCT levels at admission were signiifcantly higher in the sepsis group than in the non-sepsis group while PCIS score was signiifcantly lower in the sepsis group （P〈0.05）. The levels of serum PCT were signiifcantly higher in the death group than in the survival group while PCIS score was signiifcantly lower in the death group （P〈0.05）. The serum PCT levels showed a signiifcant negative correlation with PCIS score （r=-0.637,P〈0.01）.Conclusion：The monitoring of serum PCT levels in SIRS children is of beneift to early diagnosis of sepsis and non-sepsis and they can be used as important indexes for the assessment of the prognosis of SIRS children.
出处
《上海医药》
CAS
2014年第23期42-44,52,共4页
Shanghai Medical & Pharmaceutical Journal
基金
江西省卫生厅2013年度科技计划项目(编号:20133212)
