摘要
目的分析国际通用的帕金森病(PD)调查问卷在帕金森高危人群筛查中的敏感性及特异性。方法对2326例被调查者分别采用2种方法,即国际通用的9个问题PD调查问卷(筛查方法一)及结合PD主要的4个非运动症状[(NMS)筛查方法二]与相关既往病史进行筛查,分析问卷在PD高危人群筛查中的敏感性及特异性。确诊PD患者44例(PD组),非PD者2282例(非PD组)。结果 2326例采用筛查方法一共筛出高危人群374例,占总人数的16.08%。筛查方法二共筛出高危人群188例,占总人数的8.08%,患病率为1.89%。最终临床诊断PD44例,其中39例筛查方法一筛出的高危人群,42例筛查方法二筛出的高危人群。筛查方法一敏感性为88.64%,特异性为85.32%;筛查方法二敏感性为95.45%,特异性93.60%,2种筛查方法特异性比较,差异有统计学意义(P=0.000),而敏感性比较差异无统计学意义(P>0.05)。筛查方法二筛出的高危人群与非高危人群NMS比较,2者在嗅觉下降、快速眼动睡眠行为障碍及抑郁焦虑方面有显著差异(P=0.000)。结论筛查方法二的特异性较筛查方法一更高,但敏感性的提高不显著,筛查方法二可进一步提高对PD高危人群的筛查效率。
Objective To analyze the sensitivity and specificity of Parkinson＇s disease（PD）questionnaire in screening people at high risk of PD.Methods A total of 2326 people at high risk of PD were divided into PD group（n=44）and non-PD group（n=2282）.The sensitivity and specificity of the international PD questionnaire containing 9questions（method one）and the 4major non-motor symptoms and related past history（method two）were analyzed.Results Three hundred and seventy-four subjects at high risk of PD（16.08%）were screened out of the 2326 people with method one and 188 subjects at high risk of PD（8.08%）were screened out of the 2326 people with method two.Of the 44subjects（1.89%）who were finally diagnosed with PD,39 were detected with method one and 42 were detected with method two.The sensitivity,specificity and Youden index of method one were 88.64%,85.32%,0.74 respectively and those of method two were 95.45%,93.60%,0.89respectively（P=0.000）.No significant difference was found in sensitivity of the two methods（P〉0.05）.A significant difference was found in merosmia,REM sleep behavior disorder,depression and anxiety detected with the two methods（P=0.000）.Conclusion The specificity of method two is higher while its sensitivity is lower than those of method one.Method two can improve the sensivity and specificity of method one in screening people at high risk of PD.
出处
《中华老年心脑血管病杂志》
CAS
2016年第10期1073-1076,共4页
Chinese Journal of Geriatric Heart,Brain and Vessel Diseases
