摘要
目的探讨相位对比MRI(PC-MRI)技术在诊断非梗阻性脑积水和脑小血管病中的应用价值。方法采用Phillips 3.0 T PC-MRI设备,测量11例交通性脑积水、6例正常压力性脑积水、9例脑小血管病病人及13例健康志愿者的中脑导水管脑脊液(CSF)动力学指标(峰值流速、搏出量),并分别对4组的各项指标采用SNK-q检验进行组间两两比较。结果 1正常对照组、非梗阻性脑积水组和脑小血管病组的中脑导水管水平CSF运动呈双向、"U"型曲线,非梗阻性脑积水组的峰值流速较高,且收缩期峰值流速高于舒张期。2交通性脑积水组与正常压力性脑积水组,以及正常压力性脑积水组与脑小血管病组间CSF收缩期峰值流速的差异具有统计学意义(P<0.05),而且此3组收缩期峰值流速均高于对照组。非梗阻性脑积水组舒张期峰值流速高于正常对照组和脑小血管病组。4组间搏出量两两比较其差异均有统计学意义(均P<0.05),且非梗阻性脑积水组搏出量呈反向,脑小血管病组搏出量较对照组明显减低。结论 PC-MRI可用来诊断非梗阻性脑积水,并对鉴别非梗阻性脑积水和脑小血管病有重要价值。
Objebtive To discuss the application value of quantitative phase-contrast MRl in diagnosing non-obstructive hydrocephalus and cerebral small-vessel disease. Methods All subjects, including 11 cases of communicating hydrocephalus, six cases of normal-pressure hydrocephalus, nine cases of cerebral small-vessel disease, and 13 cases of healthy volunteers, underwent quantitative phase-contrast MRl. Cerebro-spinal fluid（CSF） velocity and flow volume were measured at the level of aqueduct of Sylvius. A SNK-q was used to compare the difference among the 4 groups. Results ① In all subjects, the CSF flow at the level of aqueduct of Sylvius was bidirectional. The velocity curve presented as ＂U＂ shape,maximum velocity of non-obstructive hydrocephalus was higher than those of the other groups, especially the maximum systolic velocity. ②Maximum diastolic velocity showed statistically significant differences between groups of communicating hydrocephalus and normal pressure hydrocephalus, and between normal pressure hydrocephalus and cerebral small-vessel disease（P〈0.05）, and the values were significantly higher in all patients groups than the normal group. Maximum diastolic velocity statistically differed between non-obstructive hydrocephalus and cerebral small-vessel disease groups（P〈0.05）. The maximal diastolic velocity was significantly higher in normal-pressure hydrocephalus group than the normal group and group of cerebral small-vessel disease. The flow volume was significantly differed among the 4 groups（P〈0.05）, the net flow volume of non-obstructive hydrocephalus was negative, the flow volume of cerebral small-vessel disease group was lower than that of normal group. Conclusion PC-MRI could be used to diagnose non-obstructive hydrocephalus and differentiate it from cerebral small-vessel disease with similar imaging finding and clinical symptoms.
出处
《国际医学放射学杂志》
2016年第5期465-467,488,共4页
International Journal of Medical Radiology
关键词
脑积水
脑小血管病
磁共振成像
相位对比法
Hydrocephalus
Cerebral small-vessel disease
Magnetic resonance imaging
Cine-phase contrast
