摘要
目的 探讨高敏肌钙蛋白I（hs-cTnI）和常规心肌标志物在微小心肌损伤（MMD）早期诊断中的价值。方法 测定172例MMD患者血清hs-cTnI以及常规心肌标志物,包括肌钙蛋白I（cTnI）、肌酸激酶（CK）、肌酸激酶同工酶（CK-MB）、肌红蛋白（Mb）、超敏C反应蛋白（hs-CRP）的浓度,并根据患者胸痛发作至采血时间窗分为〈3h组和3-6h组。另选择80健康体检者作为对照组。结果 MMD早期血清各项指标的检测值及阳性率均显著高于对照组（P〈0.05）。各单项指标的阳性率相比较,结果为hs-cTnI〉cTnI〉hs-CRP〉CK-MB〉Mb〉CK。六项指标联合检测阳性率高于单项检测（P〈0.05）。胸痛时间3-6h组各项指标水平均高于胸痛时间〈3h组、健康对照组,差异均有统计学意义（p〈0.05）。hs-cTnI、hs-CRP两项指标变化幅度最大,分别增长了11.7倍和11.8倍。结论 血清hs-cTnI可作为MMD早期诊断的敏感指标,多项指标联合检测对MMD的早期诊断有重要临床价值。
Objective To investigate early diagnosis value of the high -sensitivity troponin I （hs -cTnI） and conventional cardiac markers in minor myocardial damage （MMD）. Method The level of hs - cTnI, CK, CK - MB, hs - CRP,cTnI and Mb in 172 cases were determined. According to the client to addiction attack in pursuance of time window, the MMD group was divided into 〈 3 h group and 3 -6 h group. 80 health were checked as the control group. Results MMD group was significantly higher than healthy control in detection value and positive rate （ P 〈 0.05 ）. The positive rate of each indicator was hs - cTnI 〉 cTnI 〉 hs - CRP 〉 CK - MB 〉 Mb 〉 CK. Joint detection of six indicators were higher than single detection in positive rate（ P 〈 0.05 ）. Chest pain 3 - 6h group were higher than 〈3h group and the healthy control group（P 〈0.05）. The hs - cTnI and hs - CRP had the biggest changes,for 11.7 and 11.8 times. Conclusion The serum hs - cTnI is a sensitive indicator of MMD. Joint detection has important clinical significance for early diagnosis of MMD.
出处
《宁夏医学杂志》
CAS
2016年第10期919-921,共3页
Ningxia Medical Journal
基金
宁夏医科大学科研项目(XM201433)
关键词
高敏肌钙蛋白I
心肌标志物
微小心肌损伤
早期诊断
High -sensitivity troponin 1
Cardiac markers
Minor myocardial damage
Early diagnosis
