摘要
目的：探讨呼吸机相关性肺炎（VAP）患者病原菌分布及耐药性，以指导临床防治提供依据。方法：收集VAP患者下呼吸道分泌物进行细菌培养及药物敏感试验分析。结果：从vAP患者下呼吸道分泌物中分离出134株病原菌，以革兰阴性杆菌为主（94／134）70．15％，且呈多药耐药性；对派拉西林、头孢他啶、头孢噻肟等药物耐药，其耐药率在72．72％以上，革兰阳性球菌占（24／134）17．91％，分离的葡萄球菌均为耐苯唑西林葡萄球菌（MKS）；对青霉素、头孢唑啉耐药率〉80．00％，对大部分抗菌药耐药，对万古霉素高度敏感；分离出的真菌占（16／134）11．94％。结论：vAP患者的病原菌以革兰阴性杆菌为主，其次是革兰阳性球菌，且耐药现象严重，应加强VAP患者预防控制，缩短机械通气，合理使用抗菌药。
Objective： To investigate the distribution and drug resistance of pathogens in patients with ventilator associated pneumonia （VAP） in order to provide evidence for clinical prevention and treatment. Methods： the bacterial culture and drug sen- sitivity test of lower respiratory tract secretions from patients with VAP were collected and analyzed. Results： 134 strains of pathogenic bacteria were isolated from lower respiratory tract secretions of VAP patients, dominated by Gram negative bacilli （94/ 134, 70.15%） , and showed multi drug resistance; They wereresistant to piperacillin, ceftazidime ceftazidime, and cefotaxime, with the resistance rate at more than 72.72%. Gram positive cocci accounted for （24/134, 17.91%） , Isolated Staphylococcus was resistant to oxacillin （MRS） ; They were resistant to pemcillin and cefazolin, with the resistant rate 〉80.00%. They were resistant to most an- timicrobial drugs and highly sensitive to vancomycin;Isolated fungi accounted for 11.94% （16/134） . Conclusion： The pathogenic bacteria in VAP patients were mainly gram-negative bacilli, followed by Gram positive bacteria, with serious drug resistance. We should strengthen the prevention and control of VAP patients, shorten the mechanical ventilation, and use antimicrobial agents ratio- nally.
出处
《医学检验与临床》
2016年第5期40-42,共3页
Medical Laboratory Science and Clinics
基金
基金项目：广西卫计委科研立项项目（Z2015574）
关键词
呼吸机相关肺炎
病原菌
抗菌药
耐药性
Ventilator associated pneumonia
Pathogenic bacteria
Antibacterial drug
Drug resistance
