摘要
目的：监测患者在应用万古霉素期间的血药浓度,以制订合理的临床给药方案。方法：选取2014年6月—2015年12月福建中医药大学附属厦门第三医院收治的使用万古霉素治疗的患者38例作为研究对象。采用酶放大免疫法进行血药浓度监测,观察患者万古霉素血药浓度值、临床疗效以及肾功能情况。结果：所有患者监测血药浓度47例次,其中血药谷浓度〈10 mg/L者12例次,10-20 mg/L者21例次,〉20 mg/L者14例次;所有患者的临床有效率为76.32%（29/38）;万古霉素血药谷浓度〉20 mg/L的患者治疗后肌酐含量显著高于治疗前,差异有统计学意义（P〈0.05）,治疗前后尿素氮含量的差异无统计学意义（P〉0.05）。结论：进行万古霉素血药浓度监测可使疗效更加显著,更好地实现个体化给药、减少不良反应。
OBJECTIVE： To monitor the serum concentration of patients with vancomycin,so as to formulate the rational drug administration program for clinic. METHODS： 38 patients with vancomycin admitted into Xiamen the Third Hospital Affiliated to Fujian Traditional Chinese Medicine Universityvfrom Jun. 2014 to Dec. 2015 were selected as the research objects. Enzyme multiplied immunoassay technique was adopted to monitor the serum concentration.The serum concentration,clinical efficacy and renal function were observed. RESULTS： All patients were monitored for blood drug concentration for 47 cases,among which serum concentration 10 mg / L were 12 cases,10 ~ 20 mg / L were 21 case,and 20 mg / L were 14 cases. The total effective rate of all patients was 76. 32%. The creatinine value of patients with serum concentration 20 mg / L increased significantly compared with before treatment,the difference was statistically significant（ P〈0. 05）. Yet there was no statistical significance in urea nitrogen content before and after treatment（ P〉0. 05）. CONCLUSIONS： Monitoring of serum concentration of vancomycin can promote the efficacy,and can better achieve individualized administration,reduce the incidence of adverse drug reactions.
出处
《中国医院用药评价与分析》
2016年第9期1172-1174,共3页
Evaluation and Analysis of Drug-use in Hospitals of China
基金
福建中医药大学校管课题资助(No.XB2014059)
关键词
万古霉素
血药浓度监测
临床药师
用药分析
Vancomycin
Monitoring serum concentration
Clinical pharmacists
Analysis of drug use
