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女性Ⅱ型糖尿病患者绝经后血清性激素水平及其与糖脂代谢的关系 被引量:7

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摘要 目的探讨女性Ⅱ型糖尿病患者绝经后血清性激素水平及其与糖脂代谢的相关性。方法选择温州医科大学附属黄岩医院2014年6月-2015年6月收治的绝经后Ⅱ型糖尿病患者100例作为糖尿病组,同期健康绝经女性100例作为对照组,糖尿病组根据胰岛素抵抗指数分为胰岛素抵抗组和非胰岛素抵抗组。测定两组患者空腹血糖、空腹胰岛素、糖化血红蛋白(GHb)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、甘油三酯(TG)、总胆固醇(TC)、睾酮(T)、雌二醇(E2)、孕激素、垂体泌乳素(PRL)、促黄体生成素(LH)、促卵泡刺激素(FSH)水平。结果糖尿病组患者空腹血糖、空腹胰岛素、GHb、T、PRL、LDL-C和TC均高于对照组(P<0.05),HDL-C、E2、LH、FSH均低于对照组(P<0.05)。胰岛素抵抗组空腹血糖、空腹胰岛素、GHb高于非胰岛素抵抗组(P<0.05),胰岛素抵抗组HDL-C、TG、E2水平低于非胰岛素抵抗组(P<0.05)。糖尿病患者中E2水平与空腹胰岛素呈负相关(P<0.05),PRL与HDL-C呈正相关(P<0.05)。结论女性绝经后Ⅱ型糖尿病患者存在性激素水平和糖脂代谢异常,性激素水平异常和胰岛素抵抗及脂代谢异常有一定关系。
出处 《中国妇幼保健》 CAS 2016年第19期3993-3995,共3页 Maternal and Child Health Care of China
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