摘要
目的 研究超分割后加速放疗鼻咽癌患者的疗效和安全性。方法 将48例经CT或MRI确诊的鼻咽癌患者随机分为超分割后加速放疗组（研究组）和常规放疗组（对照组）,每组24例,对照组每周5次,每次2 Gy,总量70Gy/7周;研究组1.2 Gy/次,每周5天,每天2次,间隔不小于6 h,剂量48 Gy/40次,后2周采用后加速超分割：1.5 Gy/次,每周5天,每天2次,间隔不小于6 h,剂量30 Gy/20次,整个疗程总剂量为78 Gy/60次,共6周完成。结果 研究组与对照组治疗后36个月及60个月复发率分别为12.5%、20.8%和25.0%、37.5%,差异有统计学意义（P〈0.05）。对照组5年转移率为33.3%,研究组5年转移率为20.8%,差异显著（P〈0.01）;对照组5年总生存率为62.5%,研究组5年总生存率为83.3%,差异显著（P〈0.01）。研究组与对照组皮肤3级和4级损伤发生率比较有显著差异（P〈0.05）,粘膜2~4级损伤发生率比较有显著差异（P〈0.05）。两组晚期损伤在耳聋、放射性脑病和颈部纤维化方面比较差异有显著性（P〈0.05）。结论 超分割后加速放疗治疗鼻咽癌提高了疗效降低了复发率和转移率,提高了生存率,提高了安全性。
Objective To study the efficacy and safety of hypeffractionated accelerated radiotherapy for nasopharyngeal carcinoma. Methods 48 cases of nasopharyngeal carcinoma confirmed by CT or MRI were randomly divided into hyperfractionat- ed accelerated radiotherapy group （study group） and conventional radiotherapy group （control group） ,24 patients in each group, the control group 5 times a week,every times 2Gy,total 70 Gy/7 weeks,the study group 1.2 Gy/day,5 days a week,twice a day, at intervals of not less than 6 h, dose 48 Gy/40 times, after two weeks using accelerated hyperfractionated ： 1.5 Gy/times ,5 days a week,twice a day, at intervals of not less than 6h, dose 30 Gy/20 times throughout the course of a total dose of 78 Gy/60, a total of 6 weeks to complete. Results 36- and 60-month recurrence rates of the study group and the control group after treatment were 12.5 % ,25.0% and 20.8% , 37.5 % , the difference was statistically significant （P 〈 0.05 ）. 5-year metastasis rate in the control group was 33.3 %, and in the study group was 20.8%, the difference was significant （P 〈 0.01 ） ;5-year survival rate in the con- trol group was 62.5% , and in the study group was 83.3% , the difference was significant （P 〈 0.01 ）. Grade 3 and grade 4 skin damage between the 2 groups had significant difference （P 〈 0.05）, grade 2-4 mucosal injury between the 2 groups had signifi- cant difference（P 〈0.05）. There had significant differences in damage deafness,radiation encephalopathy and neck fibrosis be- tween the 2 groups （P 〈 0.05 ）. Conclusion Hyperfractionated accelerated radiotherapy for nasopharyngeal carcinoma can im- prove curative effects,reduce recurrence and metastasis,and improve survival rate and security.
出处
《实用癌症杂志》
2016年第9期1540-1543,共4页
The Practical Journal of Cancer
关键词
超分割后加速放疗
鼻咽癌
疗效
Hyperfractionated accelerated radiotherapy
Nasopharyngeal carcinoma
Curative effect
