摘要
目的：制备并筛选出符合ISO 6876：2001标准的聚六亚甲基单胍（PHMG）改性根管封闭剂,测定其物理性能和抑菌性能,以开发具有较强抑菌性能的新型根管封闭剂。方法：以氧化锌丁香油糊剂（ZOE）为对照,按照ISO 6876：2001规定的方法,测定不同PHMG浓度的根管封闭剂的物理性能;采用琼脂扩散法,测定其对粪肠球菌、白色念珠菌、大肠杆菌、金黄色葡萄球菌的抑菌性能;并进行统计学分析。结果：11组不同材料的流动性、固化时间、薄膜厚度和溶解率均符合ISO 6876：2001标准;固化后尺寸变化中以浓度为0.8%~2.0%的材料符合ISO6876：2001标准。PHMG根管封闭剂的抑菌性显著高于氧化锌丁香油糊剂的抑菌性（P〈0.05）。结论：成功制备出符合新型根管封闭剂要求的PHMG根管封闭剂;PHMG浓度在0.8%~1.4%之间的根管封闭剂性能最佳。
Objective：To prepare and screen the PHMG modified root canal sealing agent which was in accordance with ISO 6876：2001standard and study its physical properties and antimicrobial activity.Methods：The physical properties of the root canal sealing agents with different PHMG concentrations were measured according to ISO6876：6876rules using ZOE paste as control.The ager diffusion test was employed to evaluate the antimicrobial effects of the materials against the following microbes：E.faecalis,C.albicans,E.Coli and S.aureus in vitro.Results：The liquidity,setting time,film thickness and solubility of eleven samples met the ISO 6876：2001standard.However,only in the group which the concentration of PHMG was 0.8%to 2.0%,the dimensional change met the ISO 6876：2001standard.The antimicrobial activity of the PHMG modified root canal sealing agent was significantly higher than that of the control group（P〈0.05）.Conclusion：Modified PHMG was prepared and met the ISO standard.The root canal sealing agents with the PHMG concentrations between 0.8% and 1.2% showed the best performance.
出处
《口腔医学研究》
CAS
CSCD
北大核心
2016年第9期907-911,共5页
Journal of Oral Science Research
基金
君政基金(编号:JZSH20150005)
关键词
PHMG
根管封闭剂
物理性能
抑菌性能
PHMG
Root canal sealing agent
Physical properties
Antimicrobial activity
