摘要
异柠檬酸脱氢酶-1(isocitrate dehydrogenase 1,IDH-1)作为分子标志物在确定脑胶质瘤的分子亚型和进行个体化治疗及判断临床预后方面具有重要作用。IDH-1基因突变与胶质瘤的发生密切相关。作者主要对近年来IDH-1基因突变与脑胶质瘤的影像基因组学的关系作一综述,期望能对脑胶质瘤的早期诊断、治疗和预后有所帮助。
Isocitrate dehydrogenase 1 （IDH-1） would act as a biomarker which plays a key role in determining the molecular subtypes of gliomas and individualized treatment and prognosis. More and more studies show that IDH-1 mutation is closely associated with gliomas. This paper will review the relationship between IDH-1 mutationand imaging genomics ingliomas, Hopefully it is useful to the early diagnosis, therapy 5 and outcome of gliomas.
出处
《磁共振成像》
CAS
CSCD
2016年第9期711-715,共5页
Chinese Journal of Magnetic Resonance Imaging
基金
山东省自然科学基金(编号:ZR2014HL084)~~
关键词
异柠檬酸脱氢酶
基因突变
胶质瘤
磁共振成像
Isocitrate Dehydrogenase
Genetic mutation
Glioma
Magnetic resonance imaging
