加巴喷丁对癫痫大鼠海马神经元及P75NTR表达的影响被引量：3

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摘要加巴喷丁（gabapentin,GBP）是近几年应用于临床的新型抗癫痫药,国外一些研究已证实了加巴喷丁具有神经保护作用。本研究通过腹腔注射戊四氮建立癫痫持续状态大鼠模型,观察大鼠行为学改变,海马神经元组织学改变和凋亡相关基因P75NTR的表达变化,探讨加巴喷丁的抗癫痫作用及可能的神经保护机制。

作者臧颖卓王维平刘瑞春何斌史立信王清涛

机构地区河北省清河县人民医院神经内科河北医科大学第二医院神经内科河北省清河县人民医院神经外科河北省清河县人民医院影像科

出处《山西医药杂志》 CAS 2016年第17期2000-2002,共3页 Shanxi Medical Journal

基金河北省科技支撑计划(20100551)

关键词加巴喷丁 P75NTR 海马神经元癫痫大鼠大鼠行为学癫痫持续状态神经保护机制神经保护作用凋亡相关基因抗癫痫药

分类号 R742.1 [医药卫生—神经病学与精神病学]

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