摘要
目的：探讨不同剂量他汀对急性心肌梗死炎症因子超敏 C-反应蛋白（hs-CRP）、白细胞介素-6（IL-6）的影响。方法选取2014年1月至2015年6月治疗并接受急诊冠状动脉支架植入术的急性心肌梗死患者102例，给予抗栓、扩张冠状动脉等治疗，将其随机分为两组，一组口服20 mg 阿托伐他汀，另一组口服40 mg 阿托伐他汀，入院即刻、用药1周、用药2周抽取静脉血，检测 hs-CRP、IL-6、心肌酶等，进行组内及组间比较 hs-CRP、IL-6动态变化。结果组内比较：1周后40 mg 组 hs-CRP、IL-6水平较治疗前降低，差异有统计学意义（P 〈0.05）；20 mg组 hs-CRP 和 IL-6较基线增高，但差异未见统计学意义；2周后，40 mg 组和20 mg 组 hs-CRP、IL-6水平较治疗前明显降低，差异均有统计学意义（P 〈0.05）。组间比较：1周后40 mg 组 hs-CRP 差值、IL-6差值较20 mg 组明显降低，差异均有统计学意义（P 〈0.05）；2周后两组 hs-CRP 差值、IL-6差值比较差异未见统计学意义。结论40 mg阿托伐他汀较20 mg 阿托他汀能抑制急性心肌梗死早期（发病1周时）炎症反应。
Objective To investigate the effect of different doses of atorvastatin on levels of hs-CRP and IL-6 in patients with acute myodial infarction. Methods One hundred and two patients with acute myocardial infarction from January 2014 to June 2015 received anti-thromb,dilating-coronary, emergency coronary stenting operation and so on. They were randomly divided into two groups：one group （n = 50）was administrated with 40 mg atorvastatin,the other group（n = 52）was administrated with 40 mg atorvastatin. The serum leves of hs-CRP,IL-6 and myocardial enzymes were measured on admis-sion,1 week,2 weeks after oral atorvastatin,the dynamic changes of hs-CRP and IL-6 were compared for inner-group and inter-group. Results Inner-group comparison：the levels of hs-CRP and IL-6 in group 40 mg atorvastatin 1 week after oral atorvastatin reduced signifcantly compared with base-linel evels （P 〈 0. 05）,while the levels of hs-CRP and IL-6 increased in 20 mg group,there was no significant difference（P 〈 0. 05）. The levels of hs-CRP and IL-6 in both groups reduced signifcantly 2 weeks after oral atorvastatin compared with base-line levels（P 〈 0. 05）. Inter-group comparison：hs-CRP deviation＆amp;nbsp;and IL-6 deviation in 40 mg group were signifcantly lower than those in 20 mg group one week after oral atorvastatin（P 〈 0. 05）,while hs-CRP deviation and IL-6 deviation had no significant difference 2 weeks after oral atorvastatin. Conclusions 40 mg atorvastatin has stronger anti-inflammation effects than 20 mg atorvastatin 1 week after oral atorvastatin.
出处
《中国实用医刊》
2016年第17期24-26,共3页
Chinese Journal of Practical Medicine
