摘要
目的研究幽门螺杆菌(Hp)感染对胃黏膜中核因子NF-кB表达的影响,为慢性活动性胃炎的相关研究提供参考依据。方法选取2013年12月-2014年12月医院收治的慢性活动性胃炎患者104例为研究对象,根据患者Hp感染情况,分为Hp阳性组和Hp阴性组,各52例,对两组患者的NF-кB p65表达水平进行观察和比较,采用SPSS19.0软件进行统计分析。结果 Hp阳性组患者的NF-кB p65阳性细胞百分率为(48.98±18.34)%,显著高于Hp阴性组,差异有统计学意义(P<0.05);胃黏膜炎症等级为1、2、3级的Hp阳性患者的NF-кB p65表达水平分别为(28.34±8.34)%、(41.38±9.44)%和(64.34±12.03)%,显著高于Hp阴性组,差异有统计学意义(P<0.05);胃黏膜活动性等级为0、1、2级的Hp阳性患者的NF-кB p65表达水平分别为(32.91±11.45)%、(46.08±9.34)%和(64.32±12.30)%,显著高于Hp阴性组,差异有统计学意义(P<0.05);胃黏膜萎缩等级为0、1、2级的Hp阳性患者的NF-кB p65表达水平分别为(40.56±19.34)%、(44.34±15.93)%和(54.32±15.03)%,显著高于Hp阴性组,差异有统计学意义(P<0.05)。结论幽门螺杆菌感染可导致胃炎患者胃黏膜中核因子NF-кB表达水平升高,随着患者病情的不断进展NF-кB表达水平也呈现出升高趋势,NF-кB参与疾病的致病过程。
OBJECTIVE To study the influence of Helicobacter pylori infection on expression of gastric mucosa nuclear factor NF-кB so as to provide guidance of chronic active gastritis.METHODS A total of 104 patients with chronic active gastritis who were treated in the hospital from Dec 2013 to Dec 2014 were recruited as the study objects and divided into the Hp positive group and the Hp negative group according to the status of Hp infection,with 52 cases in each group.The level of expression of NF-кB p65 was observed and compared between the two groups of patients,and the statistical analysis was performed with the use of SPSS 19.0software.RESULTS The percentage of NF-кB p65-positive cell of the Hp-positive group was（48.98±18.34）%,significantly higher than that of the Hp-negative group（P〈0.05）.The level of expression of NF-кB p65 of the Hp-positive patients with grade 1gastric mucosal inflammation was（28.34±8.34）%,the patients with grade 2gastric mucosal inflammation（41.38±9.44）%,the patients with grade 3gastric mucosal inflammation（64.34±12.03）%,significantly higher than those of the Hp-negative patients（P〈0.05）.The level of expression of NF-кB p65 of the Hp-positive patients with grade 0gastric mucosa activity,the patients with grade 1gastric mucosa activity（46.08±9.34）%,the patients with grade 2gastric mucosa activity（64.32±12.30）%,significantly higher than those of the Hpnegative patients（P〈0.05）.The level of expression of NF-кB p65 of the Hp-positive patients with grade 0gastric atrophy was（40.56±19.34）%,the patients with grade 1gastric mucosa atrophy（44.34 ±15.93）%,the patients with grade 2gastric mucosa atrophy（54.32±15.03）%,significantly higher than those of the Hp-negative patients（P〈0.05）.CONCLUSIONThe H.pylori infection may lead to the elevated level of expression of gastric mucosa nuclear factor NF-кB,the level of expression of NF-кB shows an upward trend with continuous progress of disease,and the NF-кB involves in the pathogenesis o
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2016年第17期3875-3877,共3页
Chinese Journal of Nosocomiology
基金
四川省科技厅科技攻关基金资助项目(20131387903K)
关键词
幽门螺杆菌
感染
核因子NF-кB
胃炎
Helicobacter pylori
Infection
Nuclear factor NF-кB
Gastritis
