摘要
目的系统评价血管紧张素转换酶(ACE)基因插入/缺失(I/D)多态性与混合型运动的关联性。方法计算机检索Pub Med、EMbase、CNKI、CBM、VIP和Wan Fang Data数据库,搜集关于ACE基因I/D多态性与混合型运动能力关联性的病例-对照研究,检索时限均为建库至2015年8月1日。由2位评价者独立筛选文献、提取资料并评价纳入研究的偏倚风险后,采用Rev Man 5.3软件进行Meta分析。结果最终纳入13个病例-对照研究。Meta分析结果显示:ACE基因I/D多态性与运动员混合型运动能力相关[DD vs.DI+II:OR=0.71,95%CI(0.59,0.84),P<0.01;DD vs.II:OR=0.69,95%CI(0.54,0.87),P<0.01;D vs.I:OR=0.82,95%CI(0.72,0.92),P<0.01]。进一步分析发现,ACE基因I/D多态性与男性运动员混合型运动能力相关[DD vs.DI+II:OR=0.71,95%CI(0.57,0.89),P<0.01;DD vs.II:OR=0.70,95%CI(0.51,0.95),P=0.02;D vs.I:OR=0.80,95%CI(0.69,0.94),P=0.01],但与足球及中等距离赛跑无关联性。按人种亚组分析结果显示:ACE基因I/D多态性与高加索[DD vs.DI+II:OR=0.71,95%CI(0.59,0.87),P<0.01;DD vs.II:OR=0.69,95%CI(0.54,0.90),P=0.01;D vs.I:OR=0.80,95%CI(0.71,0.92),P<0.01]和亚洲[DD vs.DI+II:OR=0.42,95%CI(0.20,0.89),P=0.02]运动员混合型运动能力相关,与非洲运动员混合型运动能力无关联性。结论现有证据表明,ACE基因的D等位基因与混合型运动能力呈负相关。基于当前研究缺陷,本研究结论仍需进一步开展高质量病例-对照研究或队列研究予以证实。
ObjectiveTo systematically review the association between the insertion/deletion （I/D） polymorphism of angiotension-converting enzyme （ACE） gene and the athletes＇performance in mixed sports. MethodsDatabases including PubMed, EMbase, CNKI, CBM, VIP, and WanFang Data were searched from inception to August 1st, 2015 to collect case-control studies about the association between ACE I/D polymorphism and the athletes＇performance in mixed sports. Two reviewers independently screened literature, extracted data and assessed the risk of bias of included studies. Then, meta-analysis was performed using RevMan 5.3 software. ResultsA total of 13 case-control studies involving 888 athletes and 3 871 controls were included. The results of meta-analysis showed that significant association was found between ACE I/D polymorphism and the athletes＇performance in mixed sports （DD vs. DI＋II： OR=0.71, 95%CI 0.59 to 0.84, P 〈 0.01; DD vs. II： OR=0.69, 95%CI 0.54 to 0.87, P 〈 0.01; D vs. I： OR=0.82, 95%CI 0.72 to 0.92, P 〈 0.01）. Specifically, the ACE I/D polymorphism was significantly associated with the performance of male athletes in endurance sports （DD vs. DI＋II： OR=0.71, 95%CI 0.57 to 0.89, P 〈 0.01; DD vs. II： OR=0.70, 95%CI 0.51 to 0.95, P=0.02; D vs. I： OR=0.80, 95%CI 0.69 to 0.94, P=0.01）. However, this significant association was not found in football and middle-distance running sports. Subgroup analysis of ethnicity showed that, the ACE I/D polymorphism was significantly associated with the performance of Caucasian （DD vs. DI＋II： OR=0.71, 95%CI 0.59 to 0.87, P 〈 0.01; DD vs. II： OR=0.69, 95%CI 0.54 to 0.90, P=0.01; D vs. I： OR=0.80, 95%CI 0.71 to 0.92, P 〈 0.01） and Asian （DD vs. DI＋II： OR=0.42, 95%CI 0.20 to 0.89, P 〈 0.01） athletes in endurance sports, but not with African athletes. ConclusionsCurrent evidence indicates that the ACE allele D is negatively associated with the athletes＇performance in mixed sports. Due to the limitations of included stu
出处
《中国循证医学杂志》
CSCD
2016年第9期1026-1034,共9页
Chinese Journal of Evidence-based Medicine
基金
湖北省卫生计生西医类2015~2016年度一般项目(编号:WJ2015MB187)
