摘要
目的：探讨2型糖尿病（ T2DM）伴认知障碍患者静息状态下后扣带回功能磁共振的改变及其与认知功能减低的关系。方法对19例伴认知障碍T2DM患者与20例年龄、性别、教育年限与之相匹配的健康对照者进行静息态功能磁共振（ rsfMRI）扫描，计算左后扣带回ALFF值、ReHo值，并以左侧后扣带回为种子点进行全脑功能连接分析，另将所得ALFF值、ReHo值与认知评分进行相关分析。结果①左侧后扣带回的ALFF值（0．72±0．37）较健康对照组（1．09±0．46）减低，ReHo值（1．12±0．10）较健康对照组（1．14±0．11）未见明显减低。②左侧PCC与左侧内侧颞叶、左侧颞上回、左侧颞中回、右侧中央前回、右侧额上回及右侧辅助运动区功能连接减低，与左侧额中回、额下回、右侧小脑半球功能连接增强。③MoCA得分与左侧PCC 的ALFF值呈正相关。结论静息状态下T2DM认知障碍患者左侧PCC 自发功能活动、功能连接均发生改变，PCC功能的异常与T2DM认知障碍有关，其ALFF值的减低可为检测T2DM认知功能障碍提供帮助。
Objective To investigate the restingstate functional alteration in posterior cingulate cortex （ PCC） in Type 2 diabetes （ T2DM） patients with cognitive impairment and to determine the relationship of rsfMRI changes with cognitive decline. Methods Restingstate functional magnetic resonance imaging was performed T2DM patients with impaired cognition （ n=19） and healthy control subjects （ n=20） . The amplitude of low frequency fluctuations （ ALFF） and regional homogeneity （ ReHo） values were calculated in left PCC to represent the spontaneous brain activity. Using left PCC as a seed region,the functional connectivity of the whole brain was mapped. In addition,correlation analysis was conducted among ALFF,ReHo,and neuropsychological test scores. Results The ALFF values of left PCC （0.72±0.37） was decreased compared with the control group（1.09±0.46）,but the ReHo value（1.12±0.10）was not significantly changed compared with control group （1.14±0.11）. The functional connectivity was decreased with the left medial temporal lobe,left superior and middle temporal gyrus,right superior frontal gyrus,and right supplementary motor area （ SMA） ,while it was increased with the left middle frontal gyrus,inferior frontal gyrus and right cerebella. MoCA scores were positively correlated with the ALFF values of left PCC. Conclusion In resting state,the spontaneous activity and functional connectivity of PCC is altered in T2DM patients with cognitive impairement;and the function of PCC contributes to the cognitive decline associated with T2DM.The decrease of ALFF value of PCC may help to detect the cognitive decline of T2DM.
出处
《中华行为医学与脑科学杂志》
CAS
CSCD
北大核心
2016年第8期693-697,共5页
Chinese Journal of Behavioral Medicine and Brain Science
基金
国家自然科学基金项目（81371562）
关键词
2型糖尿病
静息态功能磁共振
认知障碍
后扣带回
Type 2 diabetes mellitus
Resting-state functional MRI
Cognitive decline
Pos-terior cingulate cortex
