摘要
目的:通过对糖尿病肾病和2型糖尿病患者人群进行流行病学及中医证候学的调查、分析,探讨2型糖尿病和糖尿病肾病人群的中医证候演变规律。方法:本研究利用《糖尿病肾病中医证候量表》对符合纳入标准的400例2型糖尿病和237例糖尿病肾病患者人群进行了横断面调查研究,采用聚类分析对中医证型的演变规律进行分析和归纳。结果:根据中医证候分布情况,糖尿病和糖尿病肾病均为本虚标实之证,糖尿病本虚以气阴两虚为主,标实以火热证为主;糖尿病肾病在此基础上,以阳虚更为明显,逐渐发展为阴阳两虚,瘀血证贯穿病程始终。结论:对同一疾病的不同病程阶段分别采用聚类分析进行证候学研究,这种思路和方法对探讨证候演变具有一定的实践意义。
Objective：To study evolution rules of traditional Chinese medicine（TCM） syndrome of patients with type 2 diabetes and diabetic nephropathy（DN） through the epidemiological investigation and analysis.Methods：The cross-sectional study included 237 DN patients and 400 type2 diabetic patients based on the TCM Syndrome Scale of Diabetic Nephropathy and cluster analysis was used to analyze and conclude the evolution rules of TCM syndromes.Results：The two diseases were both dei ciency in root and excess in branch.Qi and yin dei ciency with inner heat was the basic characteristic of diabetes and diabetic nephropathy was more likely to be characterized by yang dei ciency which would gradually develop into yin and yang dei ciency with blood stasis throughout the course.Conclusin：Using clustering analysis to study TCM syndromes at different stages of the same disease has certain practical significance in exploring the evolution of syndromes.
出处
《中华中医药杂志》
CAS
CSCD
北大核心
2016年第9期3707-3710,共4页
China Journal of Traditional Chinese Medicine and Pharmacy
基金
国家自然科学基金项目(No.30801467
No.81273623)
浙江省科技厅项目(No.2013C33212)
中国博士后课题基金(No.2014M551775)~~
关键词
糖尿病肾病
2型糖尿病
聚类分析
四诊信息
中医证候
Diabetic nephropathy
Type 2 diabetes
Clustering analysis
Information of four examinations
TCM syndromes
