摘要
目的:分析和探讨颅内恶性淋巴瘤的临床特点,并提高对此类疾病的认识。方法收集近10年经病理及免疫组化确诊的颅内恶性淋巴瘤患者63例,回顾分析患者的临床诊治过程中的变化及特点。结果63例患者中,经立体定向穿刺活检确诊23例,1例经开颅手术活检,34例行开颅单个病灶全切或近全切后病理确诊,5例行开颅部分切除术。确诊后19例获得随访,单纯化疗7例,生存期为12~36个月;单纯放疗3例,生存期为10~40个月;放疗+化疗9例,生存期为6~48个月。结论原发性颅内淋巴瘤是一种较少见颅内恶性肿瘤,临床表现缺乏特异性,病理确诊前诊断困难,但特异性的颅脑MRI影像可提示淋巴瘤。手术方式以立体定向穿刺活检为主,其目的主要是减压并进行病理检查。确诊后放化疗是主要的治疗手段,患者总体预后较差。
Objective To analyze and explore the clinical features of intracranial malignant lymphoma , and improve the understanding of this disease .Methods The clinical data of 63 patients diagnosed as intracranial malignant lymphoma within 10 years by pathologically and immunohistochemically were collected .The changes and characteristics in the process of clinical diagnosis and treatment were analyzed retrospectively .Results Of 63 patients, 23 were confirmed by stereotactic biopsy , 1 by open biopsy , 34 by pathological diagnosis after whole or near total resection of single lesion and 5 underwent partial resection .After being diagnosed ,19 cases received follow-up, 7 were treated with chemotherapy alone and the survival time was 12 to 36 months.3 cases were treated with radiotherapy alone and the survival time was 10-40 months.9 cases were treated with radiotherapy plus chemotherapy and the survival time was 6-48 months.Conclusions Primary intracranial lymphoma is a relatively rare intracranial malignant tumor , the clinical manifestations lack specificity and it ’ s difficult to diagnose before pathological confirmation , but the specificity of cerebral MRI images can prompt lymphoma .Operation method is given priority to stereotactic biopsy , its purpose is mainly decompression and pathology . Radiotherapy and chemotherapy is the main treatment after diagnosis .The overall prognosis of tumor was poor .
出处
《临床神经外科杂志》
CAS
2016年第4期272-275,280,共5页
Journal of Clinical Neurosurgery
关键词
淋巴瘤
原发性
颅内
lymphoma
primary
intracranial