摘要
目的:研究探讨颈动脉斑块易损性与冠心病及炎性因子之间的相关性。方法:对2012年12月至2013年9月间,首都医科大学附属北京安贞医院心内科收治的有颈动脉斑块并疑似冠心病患者92例,行颈动脉超声检查及炎性因子检测,随后行冠状动脉造影检查。颈动脉超声检查综合分析判定斑块性质分为易损组和稳定组,若受检者同时检出稳定斑块和易损斑块,则归入斑块易损组。所有患者术前进行血液炎性因子细胞间黏附分子-1(ICAM-1)、白介素-6(IL-6)及超敏C反应蛋白(hs-CRP)检测,冠状动脉造影术后统计冠心病确诊结果。结果:颈动脉斑块易损组与稳定组在性别、吸烟及LDL差异有统计学意义;颈动脉斑块易损组冠心病发生率高于颈动脉斑块稳定组(P<0.05),颈动脉斑块易损组炎性介质ICAM-1、IL-6及hs-CRP均明显高于颈动脉斑块稳定组(P<0.05)。结论:炎性因子检测说明了超声易损斑块的客观性,而颈动脉易损斑块对冠心病具有预测价值。
Objective：We investigated the relationship between carotid atherosclerosis plaque and in- flammatory factors in patients with coronary disease. Methods：We studied 92 patients with Suspicious coronary disease, referred to our department for coronary angiography. They were detected with inflammation factors levels and carotid plaque characteristics. Ultrasonography comprehensive analysis to determine the vulnerability of the plaque into the nature of group and stable group, if the subjects simultaneously detected unstable plaque and vulnerable plaque, plaque is classified as Vulnerable groups. Inflammation factors include：ICAM-1, IL-6 and hs-CRP. Statistics diagnosed with coronary disease after coronary angiography results. Results： Carotid plaque vulnerability group and stable group has significant difference in gender, smoking, low-density lipoprotein. Inflammatory factor; Carotid plaque vulnerability group coronary disease was higher than carotid plaque stabilization group （ P 〈 0. 05 ）. Carotid plaque vulnerability group of inflammatory mediators ICAM-1, IL-6 and hs- CRP were significantly higher than carotid plaque stabilization group （P 〈 0. 05 ）. Conclusion： Our findings indi- cate that Carotid plaque vulnerability inflammatory factor and coronary disease in carotid plaque vulnerability group are higher than carotid plaque stabilization group.
出处
《心肺血管病杂志》
2016年第7期551-553,共3页
Journal of Cardiovascular and Pulmonary Diseases
关键词
颈动脉斑块
炎性因子
冠心病
Carotid artery plaque
Inflammatory factors
Coronary disease
