摘要
目的探讨炎性因子与动脉硬化斑块稳定性之间的关系。方法选取颈动脉硬化斑块易损者40例为VP组,斑块稳定者40例为SP组,另选无斑块形成者40例为对照组,测定血清中IL-10、IL-18和MMP-9水平及斑块声学密度值(AD),对两组神经功能缺损评分。结果 SP组IL-18水平明显高于VP组(P<0.05);SP组IL-10,MMP-9水平明显低于VP组(P<0.05),表明VP组斑块不稳定;两组斑块声学密度值比较,SP组明显高于VP组(P<0.05);两组神经功能缺损评分比较,SP组高于VP组(P<0.05)。结论 IL-10,IL-18,MMP-9和组织因子与颈动脉粥样硬化进展有相关性,对预测不稳定斑块破裂具有较高临床价值。
Objective To investigate the relationship between inflammatory cytokines and the stability of carotid atherosclerotic plaque.Methods 80 carotid atherosclerosis patients were divided into VP group（40 cases）,plaque stability group（40 cases）,and another 40 healthy volunteers were selected as the control group.The IL-10,IL-18 and MMP-9 levels and plaque acoustic density（AD）and the NHISS were determined.Results The IL-18 of the SP group was significantly higher than the VP group（P0.05）;The IL-10 and MMP-9 of SP group were significantly lower than the VP group（P0.05）,which indicated that the plaque was instability;The AD of the SP group was significantly higher than the VP group（P0.05）;The NHISS score of the SP group was higher than the VP group（P0.05）.Conclusion The IL-10,IL-18 and MMP-9 were correlated with the progress of the carotid atherosclerosis and has important clinical value in predicting the unstable plaque rupture.
出处
《实用心脑肺血管病杂志》
2012年第6期981-982,共2页
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
关键词
炎性因子
颈动脉硬化
斑块
相关性
Inflammatory factors
Carotid atherosclerosis
Plaque
Correlation
