摘要
目的分析晚期宫颈癌患者血清肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)、血管内皮生长因子(VEGF)及肿瘤标志物水平与生存时间的相关性,以期为预测晚期宫颈癌患者的生存时间提供参考。方法选取本院2015年1月至2015年12月收治的125例晚期宫颈癌患者为研究对象,回顾性分析治疗前患者血清TNF-α、IL-6、VEGF及各肿瘤标志物水平,比较上述指标水平正常患者与水平升高患者生存时间的差异,并分析其与患者生存时间的相关性。结果血清TNF-α、VEGF、IL-6及各肿瘤标志物水平均升高的患者中位生存时间和总生存时间均显著短于上述指标水平正常患者(P<0.05)。结论晚期宫颈癌患者血清TNF-α、IL-6、VEGF及肿瘤标志物水平升高提示患者预后不良,生存时间较短,针对上述因子行靶向治疗有望改善晚期宫颈癌患者的预后。
Objective To analyze the correlation of serum levels of tumor necrosis factor-α（TNF-α）, interleukin-6（IL-6）, vascular endothelial growth factor（VEGF） and survival time in patients with advanced cervical cancer, and to provide a reference for the prediction of the survival time of the patients. Method 125 cases of advanced cervical cancer patients treated in our hospital from January 2015 to December 2015 were chosen as the research objects. Retrospective analyzed the levels of serum TNF-α, IL-6, VEGF and tumor markers before treatment. Compared the survival time of patients with normal and elevated levels of the above indexes, analyzed its correlation with the survival time of the patients. Result The median survival time and overall survival time of patients with elevated levels of serum TNF-α, VEGF, IL-6 and the tumor markers were significantly shorter than patients with normal levels of above indexes（P〈0.05）. Conclusion The levels of serum TNF-α, IL-6, VEGF and tumor markers increased in patients with advanced cervical cancer indicate a poor prognosis and shorter survival time. Targeted therapy for these factors is expected to improve the prognosis of patients with advanced cervical cancer.
出处
《中国医学前沿杂志（电子版）》
2016年第8期123-126,共4页
Chinese Journal of the Frontiers of Medical Science(Electronic Version)
