摘要
乙醇性心肌病是一种与长期大量饮酒有关的非缺血性扩张型心肌病。研究表明,适量饮酒对心血管起到保护作用,而大量饮酒会导致心脏结构和功能的改变。随着社会经济的发展,人们生活水平的提高,人们饮酒的频率和饮酒量都明显增加,乙醇性心肌病发病率随之升高。其临床前期症状不明显,以心脏结构和功能改变为主,临床期主要表现为心律失常和充血性心力衰竭。乙醇性心肌病不仅增加了家庭和社会的经济负担,而且增加了患者的死亡风险。目前其发病机制尚未完全明确,并且导致乙醇性心肌病所需的乙醇量、饮酒的持续时间一直存在争议。现就乙醇性心肌病的流行病学、乙醇的剂量-时间效应、发病机制、病理改变和治疗的最新研究进展做一综述。
Alcoholic cardiomyopathy（ ACM） is a non-ischemic dilated cardiomyopathy caused by long-term heavy drinking. Studies have shown that moderate intake of alcohol has protective effects on the cardiovascular system,while heavy consumption of alcohol may lead to changes of cardiac structure and function. With the development of the economy and improvement of people＇s living standards,the frequency and the amount of people drinking alcohol has greatly increased,which has caused a rising incidence of ACM. Preclinical ACM mainly presents with cardiac structural and functional changes,while the clinical stage mainly manifests arrhythmias and congestive heart failure.ACM not only increases the economic burden on family and society,but also increases the risks of death. The pathogenesis has not yet been completely explained and the consumption and duration of alcohol that caused ACM has been controversial until now. This article reviews the recent advances on epidemiology,alcohol dose-time effects,pathogenesis,pathology and treatment of ACM.
出处
《心血管病学进展》
CAS
2016年第4期379-383,共5页
Advances in Cardiovascular Diseases
基金
河北省卫生厅省级重大医学科研项目(No:zd2013094)
关键词
乙醇
乙醇性心肌病
饮酒
Alcohol
Alcoholic cardiomyopathy
Drinking
