摘要
酒精性心肌病是由于长期大量饮酒引起的疾病,因其临床症状与实验室检查无特异性,诊断相对困难。目前酒精性心肌病的发病机制尚未明确,有研究表明大量的酒精可使左心室心肌细胞丢失,进而引起心功能不全,线粒体损害,钙稳态失衡,心肌收缩蛋白变化等。现就酒精性心肌病的发病机制及国内外研究现状予以综述,以探讨酒精性心肌病今后的研究方向及其潜力。
Alcoholic cardiomyopathy is a disease caused by a long history of heavy alcohol abuse.Due to no specic clinical or laboratory feature,it is relatively difficult for the diagnosis.The pathophysiological mechanisms of alcoholic cardiomyopathy are poorly understood,studies have shown that excessive alcohol consumption has been associated with left-ventricular myocyte loss which causes cardiac dysfunction,mitochondrial damage,abnormalities in calcium homeostasis and the changes of myocardial contractile protein etc..Here is to make a review on the pathogenesis and research progress of alcoholic cardiomyopathy at home and abroad,to explore the direction and potential of future research on alcoholic cardiomyopathy.
出处
《医学综述》
2012年第24期4190-4191,共2页
Medical Recapitulate
