复合乳酸菌胶囊辅助治疗老年慢性阻塞性肺疾病急性加重期的效果观察被引量：3

Observation on efficacy of adjunctive therapy with lactobacillus complex capsules for elderly patients with acute exacerbation of chronic obstructive pulmonary disease

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摘要目的观察复合乳酸菌胶囊辅助治疗老年慢性阻塞性肺疾病急性加重期(AECOPD)的效果。方法老年AECOPD患者91例,按随机数字表法分为对照组47例和观察组44例。两组均给予常规治疗,观察组在常规治疗的基础上给予复合乳酸菌胶囊治疗,疗程7 d。观察两组炎症指标、肺功能、功能性呼吸困难分级评分、饮食量评分、住院时间、病死率等和不良反应发生率。结果两组治疗前白细胞计数、中性粒细胞比例、C反应蛋白、第1秒用力呼气容积占预计值百分比(FEV1%)、第1秒用力呼气容积(FEV1)/用力肺活量(FVC)、氧合指数、功能性呼吸困难分级评分、饮食量评分比较,差异无统计学意义(P>0.05);治疗后两组血中性粒细胞比例、FEV1%、C反应蛋白水平、功能性呼吸困难分级评分均明显改善(P<0.05),观察组饮食量评分较前改善。治疗后观察组白细胞计数、中性粒细胞比例低于对照组(P<0.05),且住院时间短于对照组(P<0.05)。治疗后两组皮疹、腹泻和真菌感染发生率比较,差异无统计学意义(P>0.05)。结论对于老年AECOPD患者,在常规治疗的基础上辅以复合乳酸菌胶囊有助于控制感染、改善食欲,减少住院时间,安全性好。 Objective To observe the efficacy of adjunctive therapy with lactobacillus complex capsules for elderly patients with acute exacerbation of chronic obstructive pulmonary disease（AECOPD）. Methods Ninety-one elderly patients with AECOPD were divided into control group （n = 47） and observation group （n = 44） using the random number table. Both groups received conventional therapy, and the observation group was administered laetobacillus complex capsules on the basis of conventional therapy. The therapeutic course was 7 days. The inflammation index, lung function, score of functional dyspnea grading, food intake score, hospital stay, fatality rate and incidence rate of adverse reaction were compared between the two groups. Results There were no statistical differences in WBC count, neutrophil ratio, C-reaction protein, percentage of predicted forced expiratory volume in one second （FEV1% ）, predicted forced expiratory volume in one second （ FEV1 ）/（ forced vital capacity, FVC）, oxygenation index, score of functional dyspnea grading or food intake score between the two groups before treatment（ P 〉 0.05 ）. After treatment, the neutrophil ratio, FEV1% , C-reaction protein and score of functional dyspnea grading improved significantly in both groups （ P 〈 0.05 ） , and food intake score in the observation group was improved （ P 〈 0.05 ）. After treatment, WBC count and neutrophil ratio were lower and the hospital stay was less in the observation group compared to the control group （ P 〈 0.05 ）. After treatment, there was no significant difference in the incidence rate of skin rash, diarrhea or fungal infection between the two groups （ P 〉 0.05 ）. Conclusion For the elderly patients with AECOPD, adjunctive therapy with lactobaeillus complex capsules on the basis of conventional therapy is helpful for controlling infection, improving appetite and reducing hospital stay. It obtains a good safety.