摘要
目的:探究MFG-E8与老年CHD患者MIRI的相关性,为将来CHD患者进行缺血再灌注治疗提供帮助。方法:选取我院收治的94例CHD患者作为观察组,并进行再灌注手术;选因胸部不适且冠脉未见明显狭窄的患者作对照组;检测手术前和手术后24、48h各组MFG-E8及下游因子MCP-1、TGF-β1,炎症因子hs-CRP、IL-6、ICAM-1的变化,分析MFG-E8与各项指标及MIRI的相关性。结果:观察组各时间点MFG-E8均显著低于相应时间点的对照组(P<0.05);术后24、48h MFG-E8较术前均显著升高(P<0.05),且术后48h高于24h;对照组各时间点MFG-E8变化差异不明显(P>0.05)。对照组各时间点炎症因子hs-CRP、IL-6、ICAM-1变化差异不明显(P>0.05);观察组各时间点炎症因子hs-CRP、IL-6、ICAM-1均明显高于对照组(P<0.05);炎症因子术后含量显著高于术前(P<0.05),但hs-CRP在术后48h显著低于24h,IL-6、ICAM-1随时间的延长而增加;炎症因子与MFG-E8程度成负相关。观察组不同时间点血清TNF-β、MCP-1均显著高于对照组(P<0.05);术后TNF-β、MCP-1显著高于术前,且TNF-β、MCP-1在48h显著高于24h,差异具有统计学意义(P<0.05);TNF-β、MCP-1与MFG-E8成正相关。结论:炎症反应在老年MIRI中起着重要作用,MFG-E8对炎症起防御作用,有助于减轻MIRI,为将来进行心肌缺血再灌注治疗提供帮助。
[ABSTRACT]Objective：To explore the correlation between MFG-E8 and CHD in elderly patients with MIRI,and to pro-vide help for CHD patients with ischemic reperfusion therapy in the future.Methods：A total of 94 CHD patients in our hospital were selected as the observation group and treated with reperfusion operation.The patients with chest discomfort and no signif-icant stenosis of coronary artery were selected as control group.Before and after operation,the changes of MFG-E8 and the downstream factor MCP-1,TGF-β1,inflammatory factors hs-CRP,IL-6 and ICAM-1 in each group were detected in 24h andnbsp;48h after operation,Analysing the correlation between MFG-E8 with various indexes and MIRI.Results：MFG-E8 at each time point of the observation group were significantly lower than that of the control group（P 〈 0.05 ）,and were significantly in-creased as comparison of the preoperative（P 〈0.05 ）,and the level of MFG-E8 in postoperative 48h was higher than that at 24h;in the control group,the change of MFG-E8 and inflammatory factors hs-CRP,IL-6,ICAM-1 at different time points was not obvious （P 〉0.05）;the level of inflammatory factors hs-CRP,IL-6,ICAM-1 at each time points of the observation group were significantly higher than that of the control group,P value of each group was less than 0.05;the levels of inflam-matory factors were significantly higher than those preoperative（P 〈0.05）,the level of hs-CRP at 48h was significantly lower than that at 24h,IL-6 and ICAM-1 were increased over time;the level of inflammatory factors were negatively correlated with MFG-E8.In the observation group,the serum TNF-β,MCP-1 and at different time points were significantly higher than those in the control group （P 〈0.05）.TNF-β and MCP-1 were significantly higher than that before operation,and the TNF-β and MCP-1 in 48h were significantly higher than those in 24h,the difference was statistically significant （P 〈0.05）;TNF-β and MCP-1 were positively correlated with MFG-E8.Conclusion：Inflamma
出处
《海南医学院学报》
CAS
2016年第17期1936-1939,共4页
Journal of Hainan Medical University
基金
上海中医药大学附属第七人民医院人才培养计划(xx2015-14)~~
