摘要
目的探讨新生儿重度高胆红素血症患儿采用同步换血法治疗的临床疗效,进一步为临床治疗提供参考依据。方法选取2012-01—2014-12间广东省肇庆市第一人民医院收治的97例重度高胆红素血症新生儿作为研究对象,对所有患儿行外周动脉、静脉同步换血疗法,在换血的过程中严格监测患儿的各项生命体征,并记录患儿换血前后的胆红素水平、血常规及肝肾功能、凝血功能、电解质的变化。结果经过治疗患儿换血前、后总胆红素、间接胆红素、血小板、血红蛋白差异均有统计学意义(P<0.05);白细胞、血钾、钠、钙无明显变化,差异均无统计学意义(P>0.05);换血后凝血PT、APTT及FIB等指标无明显变化(P>0.05)。结论对重度高胆红素血症患儿采取同步换血疗法可快速降低患儿体内胆红素指标水平,对积极治疗溶血、控制感染、预防和减轻胆红素脑病有着重要的临床意义。换血后血小板下降多在3 d内自行改善,对凝血功能无造成影响。
Objective To explore the clinical effect of synchronous exchange transfusion for newborn severe hyperbilirubinemia,in order to provide references for clinical treatment. Methods 97 newborns with severe hyperbilirubinemia from January,2012 to December,2014 were selected. All patients accepted the synchronous exchange transfusion via cycle arterial and vein; monitored the various vital signs in the process of exchanging transfusion; and recorded the changes of bilirubin levels,blood routine,liver and kidney function,blood coagulation function and electrolyte. Results After treatment,total bilirubin,indirect bilirubin,platelets,hemoglobin and other indicators were statistically significant（ P〈0. 05）; leukocytes,potassium,sodium and calcium had no significant change. There was no significant difference（ P〉0. 05）. After exchange,transfusion coagulation PT,APTT and FIB and other indicators had no significant change（ P〉0. 05）.Conclusion Children with severe hyperbilirubinemia take synchronous high blood transfusion therapy in children can quickly reduce target levels of bilirubin in the body. For active treatment of hemolysis,infection control,prevention and mitigation of bilirubin disease has important clinical significance. After the exchange transfusion,platelet decline has more self- improvement ability within 3 days,with no impact on coagulation.
出处
《黑龙江医学》
2016年第8期729-731,共3页
Heilongjiang Medical Journal
关键词
新生儿
重度高胆红素血症
同步换血疗法
临床疗效
Newborns
Hyperbilirubinemia
Synchronous exchange transfusion therapy
Clinical efficacy
