摘要
目的探讨醒脑开窍针法不同应用时机治疗急性脑梗死的疗效。方法选择急性脑梗死患者66例为研究对象,按照随机自愿原则分为A组、B组、C组。3组均接受相同的常规治疗,A组在发病24 h内给予醒脑开窍针法,B组在发病7 d时开始醒脑开窍针刺治疗,C组在发病14 d时开始醒脑开窍针刺治疗。经连续治疗4个疗程后,统计3组临床疗效,观察治疗前后神经功能、认知功能、日常活动能力以及残障程度改善情况,检测血清炎性细胞因子变化情况。结果 A组治疗后总有效率显著高于B组和C组(P均<0.05);治疗后,3组NIHSS评分、OHS评分均显著降低(P均<0.05),MMSE评分、BI评分均显著升高(P均<0.05),A组NIHSS评分、OHS评分均显著低于B、C组(P均<0.05),而MMSE评分、BI评分均显著高于B、C组(P均<0.05),B组和C组各项评分比较差异均无统计学意义(P均>0.05);3组血清TNF-α、IL-6及CRP水平均显著降低(P均<0.05),且A组均显著低于B、C组(P均<0.05),B组和C组比较差异均无统计学意义(P均>0.05)。结论醒脑开窍针法最佳介入时机为急性脑梗死病发7 d内,能够有效改善患者神经缺损和病灶炎性病理生理状况,促进认知功能的恢复。
Objective It is to explore the clinical effect of Xingnao Kaiqiao？ acupuncture at different application timing on acute cerebral infarction. Methods According to the principle of voluntary random, 66 cases of patients with acute cerebral in- farction were divided into group A, group B and group C. The three groups were given the same routine clinical therapy, and group A, group B and group C were treated with Xingnao Kaiqiao acupuncture respectively within 24 hours, in 7 days and in 14 days after disease attack. After four consecutive treatment period, curative effects were compared, the changes of nerve function, cognitive function, daily activity ability and degree of disability and the serum levels of inflammatory cytokines before and after treatment were observed. Results The total effective rate of group A was significantly higher than that of group B and group C （ P 〈 0.05 ） ; After treatment, the NIHSS scores and OHS scores of the three group were significantly reduced （ P 〈 0.05 ） , and the MMSE scores and BI scores were increased（P 〈0.05） ; the NIHSS scores and OHS scores were significantly lower while MMSE scores and BI scores were higher in group A than those in group B and group C（P 〈0.05）. There was no significant difference in the scores between group B and group C. After treatment, the levels of serum TNF - α, IL - 6 and CRP in the three group were significantly reduced （P 〈 0.05） , and the decrease was more significant in group A than those in group B and group C （P 〈 0. 05 ）. There was no significant difference in the levels between group B and group C. Conclusion The optimal timing of application for Xingnao Kaiqiao acupuncture in the treatment for acute cerebral infarction is within 7 d, which can effectively improve nerve defect and inflammatory pathological physiology, promote the recovery of cognitive function.
出处
《现代中西医结合杂志》
CAS
2016年第26期2875-2878,共4页
Modern Journal of Integrated Traditional Chinese and Western Medicine
关键词
急性脑梗死
醒脑开窍针法
介入时机
炎症反应
认知功能障碍
acute cerebral infarction
Xingnao Kaiqiao acupuncture
application timing
inflammatory response
cogni- tive dysfunction
