摘要
目的研究30-79岁健康人群不同年龄、不同性别Ⅰ型胶原交联C-末端肽（CTX-1）、抗酒石酸酸性磷酸酶（TRACP）、骨碱性磷酸酶（BALP）、骨钙素（OC）与腰椎骨密度（bone mineral density,BMD）的相关性。方法采用Hologic Discovery WA型骨密度仪检测腰椎正位（L1-4）BMD,采用酶标免疫分析仪检测血清CTX-1、TRACP、BALP、OC水平。将1228例受试者的检测结果按不同性别、10岁为1个年龄段进行分组,应用SPSS 19.0软件进行统计分析。结果女性30-49岁年龄段CTX-1、TRACP、BALP、OC与腰椎BMD均无明显相关性,50岁以后CTX-1、TRACP显著升高,与BMD呈负相关。女性BALP、OC在50-59岁年龄段明显升高,与BMD负相关,60岁以后开始下降,与BMD呈正相关;男性30-59岁各年龄组CTX-1、TRACP、BALP与腰椎BMD均无相关性,60岁以后CTX-1、TRACP、BALP均明显升高,与BMD负相关。男性OC水平随年龄缓慢下降,但各年龄段与BMD均无相关性;在30-49岁年龄段TRACP、CTX-1、BALP、OC各指标性别间不存在差异,50岁以后同年龄组性别间差异有统计学意义（P〈0.05）,且女性高于男性。结论 TRACP、CTX-1、BALP、OC是监测骨代谢变化的重要技术手段,尤其对女性骨质疏松具有较高的敏感性和特异性。
Objective To study the associations of serum levels Type I collagen carboxy-terminal peptide（ CTX-1）,Tartrate resistant acid phosphatase（ TRACP）,Bone specific alkaline phosphatase（ BALP） and Osteocalcin（ OC） with lumbar spine BMD in 30 to 79 year-old healthy individuals stratified by age and gender. Methods lumbar spine BMD（ L1-4） was measured by Hologic Discovery WA bone mineral densitometer,and enzyme immunoassay analyzer was used to measure the levels of bone remodelling markers（ CTX-1,TRACP,BALP and OC） in the serum. The 1228 participants were grouped according to gender and age（ per 10 years）. SPSS 19. 0 was used for statistical analysis. Results In females,the levels of CTX-1,TRACP,BALP and OC had no significant correlation with lumbar spine BMD in the 30-49 age groups; CTX-1 and TRACP increased significantly and had negatively correlation with lumbar spine BMD after the age of 50; levels of BALP and OC increased significantly and had negatively correlation with BMD in the 50- 59 age group,then began to decline and were positively correlated with BMD after the age of 60. In males,the levels of CTX-1,TRACP and BALP had no significant correlation with lumbar spine BMD in the 30-59 age groups,but CTX-1,TRACP,BALP increased significantly and were negatively correlated with BMD after the age of 60. The level of OC declined gradually with age,but had no significant correlation with BMD in all age groups in male. The measure values of TRACP,CTX-1,BALP and OC were not significantly different between males and females in the 30-49 age groups,but different significantly between males and females in the same age group after the age of 50（ P〈0. 05）,with the measures values in females higher than those of males. Conclusion TRACP,CTX-1,BALP,OC are important markers for monitoring changes in bone metabolism,in particular,they have high sensitivity and specificity for osteoporosis in female.
出处
《中国骨质疏松杂志》
CAS
CSCD
北大核心
2016年第8期958-961,共4页
Chinese Journal of Osteoporosis
关键词
骨代谢标志物
Ⅰ型胶原交联C-末端肽
抗酒石酸酸性磷酸酶
骨碱性磷酸酶
骨钙素
腰椎
骨密度
性别
年龄
Bone remodelling markers
Type I collagen cross linking C-terminal peptide
Tartrate resistant acid phosphatase
Bone alkaline phosphatase
Osteocalcin
Lumbar spine
Bone mineral density
Gender
Age
