摘要
目的分析男性血清Ⅰ型原胶原氨基端前肽(PINP)、β-胶原降解产物(β-crosslaps)及N端骨钙素(N-MID)随年龄变化及其与骨密度(BMD)的关系。方法采用电化学发光免疫分析法分析血清PINP、β-crosslaps及N-MID的含量,采用美国GE公司生产的LunarProdigy双能X线(DXA)骨密度仪检测各部位BMD。结果 PINP、β-crosslaps及N-MID与年龄呈负相关(r=-0.240～-0.253,P<0.05),30～49年龄段处于较高且稳定的水平(PINP:46.98～46.79μg/L,β-crosslaps:0.46μg/L,N-MID23.65～23.08μg/L)。随年龄增长逐渐下降,PINP在60～69年龄段达最低水平(32.28μg/L),β-crosslaps及N-MID在80岁以后下降加速(0.30μg/L、14.75μg/L)。校正年龄、身高、体质量及体质量指数的偏相关分析显示,PINP和β-crosslaps与各部位BMD皆呈负相关(r=-0.155～-0.310,P<0.05);除L1-4外,N-MID与各部位BMD均呈负相关(r=-0.151～-0.189,P<0.05)。按BMD分组,方差分析显示70岁以上男性骨质疏松组PINP、β-crosslaps及N-MID高于正常骨量组(P<0.05),骨质疏松组β-crosslaps及N-MID高于低骨量组(P<0.05)。结论 PINP、β-crosslaps及N-MID是敏感且特异反映男性骨转换的指标;特异性强的骨形成和骨吸收指标增加为骨代谢转换率增高的表现,提示70岁以上男性骨质疏松症患者处于高骨转换状态,骨量快速丢失。
Objective To study the age-related changes of serum procollagen I N-terminal Propeptide （PINP）, β-crosslaps and N-MID Osteocalein （N-MID） of men, as well as their correlations with bone mineral density （BMD）. Methods The levels of serum PINP, β-crosslaps and N-MID were tested by electroehemiluminescence immunoassay; BMD of lumbar spine 1-4, femoral neck, wards, troch and femur were measured by American GE company＇s Lunar Prodi- gy dual energy X ray （DEXA） absorptiometry. Results ①PINP, 15 the-crosslaps and N-MID were negative correlated with age （r = -0. 240 - -0. 253, P 〈0. 05）, serum PINP, β-crosslaps and N-MID were relatively high and stable at the age of 30 - 49 （ PINP46. 98 - 46. 79 μg/L; β-crosslaps 0. 46 μg/L, N-MID 23.65 - 23.08 μg/L）, then PINP de- creased gradually with aging to a nadir level at the age group of 60 - 69 （ PINP 32. 28 μg/L）, while β-crosslaps and N-MID declined to the lowest point in age group of 80 - （0. 30 μg/L and 14. 75 μg/L）. ②After adjustment for age,height, weight and BMI, serum PINP andl3-crosslaps were nagatively correlated with BMD of multiple skeletal sites （r = - 0. 155 - 0. 310, P 〈 0. 05 ） ; N-MID was inversely associated with BMD of multiple skeletal sites except L1-4 （r= -0. 151 - -0. 189, P 〈0. 05）. ③ Analysis of variance showed, while men over 70 years divided into groups acorrding to BMD, the PINP, β-crosslaps and N-MID of osteoporosis group were significantly higher than that of normal bone mass group, P 〈 0. 05 ; 13-crosslaps and N-MID of osteoporosis group is significantly higher than that of the low bone mass group, P 〈0. 05. Conclusion PINP, β-crosslaps and N-MID are sensitive and specific bone biochemical markers which are indicators of the bone turnover in men. Monitoring these markers are helpful to the prevention and early treat- ment of osteoporosis. In men over 70 years old, the bone biochemical markers of low bone mass and osteoporosis group were significantly increased compared with th
出处
《中华骨质疏松和骨矿盐疾病杂志》
2012年第3期179-185,共7页
Chinese Journal Of Osteoporosis And Bone Mineral Research
基金
军队中医药科研专项课题重点项目(10ZYZ115)
广东省科学技术厅-广东省中医药科学院联合科研专项(2011B032200005)
关键词
Ⅰ型原胶原氨基端前肽
β-胶原降解产物
N端骨钙素
骨密度
相关性
procollagen Ⅰ N-terminal propeptide
β-crosslaps
procollagen Ⅰ N-terminal peptide
osteocalcin
bone mineral density
correlation
