摘要
目的 探讨血清抗磷脂酶A2受体抗体（抗PLA2抗体）在特发性膜性肾病（IMN）治疗中的意义。方法 选取2015年7~12月在河南省人民医院肾内科住院并行肾活检的40例IMN患者,采用酶联免疫吸附法（ELISA）检测血清中抗PLA2抗体的滴度,以20 RU/ml〈抗PLA2抗体滴度〈100 RU/ml、100 RU/ml〈抗PLA2抗体滴度〈500RU/ml、抗PLA2抗体滴度〉500 RU/ml分为低滴度组（17例）、中滴度组（11例）、高滴度组（12例）,同时给予足量激素联合环磷酰胺治疗,分别测定患者治疗前及治疗后1个月,3个月,6个月24 h尿蛋白及血清白蛋白水平。结果 40例IMN患者,在治疗后1个月,3个月,6个月后达到临床完全缓解（CR）、部分缓解（PR）的例数,低抗体滴度组多于中滴度组多于高滴度组（P〈0.05）;各时期血清白蛋白水平相比,低抗体滴度组高于中滴度组高于高滴度组（P〈0.05）。结论 在IMN患者中,血清抗磷脂酶A2受体抗体滴度与临床疗效呈负相关。
Objective To investigate the significance of serum phospholipase A2 receptor antibody in patients with idiopathic membranous nephropathy.Methods 40 cases of IMN patients with concurrent renal biopsy in the department of renal medicine of He＇nan province people＇s hospital were selected from July to December 2015.By enzyme linked immunosorbent assay（ELISA） for the detection of serum anti PLA2 antibody titer,with 20 RU/ml anti PLA2 antibody titer 100 RU/ml,100RU/ml anti PLA2 antibody titer 500 RU/ml,anti the PLA2 antibody titer 500 RU/ml points for low titer group（17 cases）,middle titer group（11 cases） and the high titer group（12 cases）,while giving enough of steroid and cyclophosphamide treatment were measured in patients before treatment and after 1 month,3 months,6 months and 24 h urine protein and serum albumin level.Results 40 cases of patients with IMN.At 1 month after treatment,3 months and after 6 months to clinical complete remission（CR）,partial remission（PR） of the number of cases and low antibody titer group was higher than that of middle titer group was higher than that of the high titer group（P 0.05）.Compared to the period,the serum albumin level and low titers were higher than middle titer group was higher than that of the high titer group（P 0.05）.Conclusion In IMN patients,serum anti phospholipase A2 receptor antibody titers were negatively correlated with clinical efficacy.
出处
《中国继续医学教育》
2016年第22期27-29,共3页
China Continuing Medical Education
关键词
血清抗磷脂酶A2受体抗体
特发性膜性肾病
治疗
Phospholipase A2 receptor antibody
Idiopathic membranous nephropathy
Treatment
