摘要
目的：探讨肺硬化性血管瘤（SHL）的临床影像学表现及病理特征。方法：回顾性分析7例肺硬化性血管瘤患者的临床症状、影像学表现、组织化学及免疫组织化学染色特点。结果：7例患者中男性2例（28.57%）,女性5例（71.43%）;左肺6例,右肺1例;年龄18~59岁,平均44.57岁,体检发现6例（85.71%）,无症状者5例。CT检查2例为SHL,4例为错构瘤,1例为肺癌。组织学上有实体型、乳头型、硬化型和血管瘤样等4种结构,多为2~3种结构的混合型,肿瘤由圆形间质细胞和表面立方形细胞两种组成;免疫组织化学标记两种细胞均表达TTF-1、EMA、Vim,立方细胞表达CK、CK7,圆形细胞表达ER、PR,两种细胞均不表达Cg A、Syn、CD34。7例患者术后随访2~36个月,均无严重并发症、无复发、无转移。结论：肺硬化性血管瘤术前诊断困难,手术切除是治疗本病的有效方法并能明确诊断,免疫组织化学有助于诊断和鉴别诊断。
Objective： To investigate the clinical pathological characteristics and imaging features of sclerosing hemangioma of the lung. Methods： The clinical symptoms,imaging feature,immunohistochemical and histochemical staining characteristics were reviewed in 7 cases of PSH. Results： In 7 cases,male,female,left lung,right lung,routine examination,symptomless were 2（ 28. 57%）,5（ 71. 43%）,6,1,6（ 85. 71%）,5,respectively. The average age was44. 57 and range from 18 to 59 years. Based on CT results,2 cases were diagnosed as SHL,4 cases was diagnosed as pulmonary hamartoma,1 case was diagnosed as lung cancer. 7 cases showed a mixture of the following four histological patterns： Solid,papillary,sclerotic and hemangioma- like. The tumor was composed of two district cellular components,the round or polygonal cells and the cuboidal or surface cells. Immunohistochemical staining revealed the both kinds of cells expressed TTF- 1,EMA,Viment,The cuboidal cells expressed CK,CK7,the round or polygonal cells expressed ER,PR. Two kinds of cells do not express Cg A,Syn,CD34. In follow- up of 2 ~ 36 months after surgery,all patients had no serious complications,no recurrence,no metastasis. Conclusion： Sclerosing hemangioma of the lung is difficult to be diagnosed before operation. Operation resection is an effective method for treating this disease and diagnosis. Immunohistochemistry is helpful in the diagnosis and differential diagnosis.
出处
《现代肿瘤医学》
CAS
2016年第18期2902-2905,共4页
Journal of Modern Oncology
关键词
肺硬化性血管瘤
临床病理
免疫组化
sclerosing hemangioma of the lung
clinicopathological
immunohistochemistry
