摘要
类鼻疽伯克霍尔德菌(Burkholderia pseudomallei,类鼻疽菌)是一种革兰阴性短杆菌,现被美国疾病预防控制中心提升为I类致病菌严加防范。类鼻疽菌直接从环境感染人类和多种动物,且抗生素耐药严重,一旦引起败血症会有很高的死亡率。为了更好地指导类鼻疽病的临床治疗和研究类鼻疽菌的致病机制,建立类鼻疽病动物模型是必不可少的环节。笔者对现有的类鼻疽病动物模型从易感动物、感染途径、动物品系和模型评价几个方面进行总结阐述。
Burkholderia pseudomallei is one of gram-negative Burkholderia species,classified as＂titer 1＂agent by CDC in2006. Melioidosis can be acquired from the environment through respiratory tract and mucosa. It is notorious because of high resistance and mortality rate. A stable and reliable animal model of melioidosis is indispensable in relation to the better investigations on Burkholderia pseudomallei involved in pathogenesis,clinical treatment and outcomes. To date,there are several kinds of successful models established for melioidosis,on mammals or invertebrates. Based on previous studies,we summarized characteristics including susceptibility,strains,infection route and model evaluation for the mouse model.
出处
《微生物学免疫学进展》
2016年第4期65-69,共5页
Progress In Microbiology and Immunology
