摘要
目的对64例晚期肺癌患者进行综合治疗,探讨此种疗法对患者生存期及生存质量的影响。方法将经病理检查确诊的64例肺癌患者随机分为观察组与对照组,各32例。2组均根据症状给予对症治疗,包括镇痛、纠正低蛋白血症等,此外观察组在上述治疗基础上给予心理干预和社会支持。随访1年,比较2组患者的肿瘤进展时间(TTP)、中位生存期(MSD)及半年、1年生存率,并对其生存质量作出评价。结果随访期1年内,2组TTP分别为(4.72±1.56)、(6.29±2.13)月,观察组低于对照组(P<0.05);2组MSD分别为(9.32±2.28)、(7.87±1.54)月,观察组高于对照组(P<0.05)。对照组随访期间6、12、24、36、48、60个月时的生存率分别为59.4%、46.9%、31.2%、15.6%、9.4%与6.3%,观察组分别为93.8%、75.0%、56.3%、37.5%、31.2%与25.0%,组间比较观察组不同时期的生存率均高于对照组,差异具有统计学意义(P<0.05)。此外观察组患者生理状况、社会家庭状况、功能状况、情感状况、肺癌特异性状况及总体生活质量评分等均高于对照组,差异具有统计学意义(P<0.05)。结论在对晚期肺癌患者进行姑息治疗的同时配合心理与社会支持等综合疗法,可有效控制疾病进展,延长生存期,提高患者生存质量。
Objective To study the impact of multimodality therapy on lifetime and life quality of 64 cases of advanced lung cancer. Methods 64 patients with lung cancer were selected and confirmed through pathological examination. The patients were randomly divided into the observation group and the control group,32 cases in each group. Both groups received the symp- tomatic treatment like analgesia, correction of hypoproteinemia, etc. On the basis of the control group, the observation group also a- dopted the mental intervention and social support. During 1-year follow-up,TrP, MSD, and 6-month and l-year survival rates after treatment were compared. The, quality of life was evaluated. Results During 1-year follow-up, TFP of the observation group and the control group were （4.72 ± 1.56） and （6.29 ± 2.13 ） （ P 〈 0.05 ） ; MSD of the observation group and the control group were （9.32 ± 2.28 ） and （7.87 ± 1. 54） （ P 〈 0.05 ） ;6-, 12- ,24-,36- ,48- ,60-month survival rates of the control group were 59.4%, 46.9% ,31.2% ,15.6% ,9.4% and 6.3% ;the survival rate of the observation group were 93.8% ,75.0% ,56.3% ,37.5%, 31.2% and 25.0%, at different time periods, the survival rates of the observation group were higher than those of the control group （P 〈 0.05 ） ; the physiological status, social family status, functional status, emotional status, specificity of lung cancer and total score of life quality of the observation group were higher than those of the control group （ P 〈 0.05 ）. Conclusion For pa- tients with advanced lung cancer, the palliative treatment combined with muhimodality therapy such as mental and social support can efficiently control the progression of illness, extend the lifetime and improve the patientg quality of life. It is worthy of clinical promotion and application.
出处
《实用癌症杂志》
2016年第8期1290-1292,共3页
The Practical Journal of Cancer
关键词
综合治疗
晚期
肺癌
生存期
生存质量
Multimodality therapy
Advanced
Lung cancer
Lifetime
Quality of life
