摘要
目的:观察艾灸配合自血穴位注射疗法与单纯艾灸疗法对肺脾气虚型变应性鼻炎(AR)的疗效,并探讨其作用机制。方法:将75例符合标准的患者按照随机数字表法分为艾灸配合自血穴位注射组(联合组,37例)和艾灸组(38例)。联合组采用艾灸与自血穴位注射相结合的方法,艾灸双侧迎香穴,自血穴位注射穴取双侧肺俞、脾俞和足三里;艾灸组穴取双侧迎香、肺俞、脾俞和足三里穴。自血穴位注射每周2次,艾灸每日1次,7d为一疗程,共观察4个疗程,半年后随访。采用鼻结膜炎生活质量量表(RQLQ)于治疗前、治疗后及半年后随访比较两组的评分情况,并比较两组近远期疗效以及血清免疫学指标干扰素-γ(IFN-γ)、白细胞介素-4(IL-4)和免疫球蛋白E(IgE)含量的变化。结果:治疗后联合组显效率为75.68%(28/37),高于艾灸组的52.63%(20/38,P<0.05);随访时艾灸组显效率47.37%(18/38)优于联合组24.32%(9/37,P<0.05)。两组患者在治疗后、随访时鼻结膜炎生活质量各个方面均较治疗前明显改善(P<0.01,P<0.05);治疗后联合组在日常生活、睡眠、非鼻/眼症状、行为问题方面改善优于艾灸组(均P<0.05);随访时艾灸组在日常生活、睡眠、非鼻/眼症状、行为问题、眼部及鼻部症状以及情感反应方面改善优于联合组(均P<0.05)。两组治疗后血清IFN-γ、IgE、IL-4含量与治疗前相比差异均有统计学意义(P<0.01,P<0.05),联合组与艾灸组比较,差异有统计学意义(P<0.05)。结论:艾灸配合自血穴位注射疗法能显著改善肺脾气虚型AR患者近期生活质量,其作用机制可能与纠正Th1和Th2免疫反应失衡有关。
Objective To observe the effects of moxibustion combined with autohemotherapy of acupoint injection and simple moxibustion for allergic rhinitis（AR）with qi deficiency of lung and spleen and to explore its mechanism.Methods By random number table,75 patients who matched the criteria were assigned into a moxibustion combined with autohemotherapy of acupoint injection group（a combination group,37cases）and a moxibustion group（38cases）.In the combination group,moxibustion was used at bilateral Yingxiang（LI 20）and injection bila-teral Feishu（BL 13）,Pishu（BL 20）and Zusanli（ST 36）.In the moxibustion group,moxibustion was applied bilaterally at all the above acupoints.Acupoint injection was given twice a week,and moxibustion once a day,seven days as a course.The patients were observed for four courses and followed up half a year after treatment.Rhinoconjunctivitis quality of life questionnaire（RQLQ）was compared before and after treatment and at follow-up.The short-term and long-term effects as well as the changes of interferon-γ（IFN-γ）,interleukin-4（IL-4）and immunoglobulin E（IgE）were observed in the two group.Results After treatment,the obviously effective rate of the combination group was 75.68%（28/37）,which was higher than 52.63%（20/38）of the moxibustion group（P〈0.05）.But at follow-up,the obviously effective rate of the moxibustion group was 47.37%（18/38）,which wasbetter than 24.32%（9/37）of the combination group（P〈0.05）.Life quality of the two group in all aspects after treatment and at follow-up were apparently improved compared with the baseline（P〈0.01,P〈0.05）.After treatment,the life quality,sleep condition,non nasal-eye symptoms,behavior issue of the combination group were superior to those of the moxibustion group（all P〈0.05）,and at follow-up,the above outcomes,the eye and nasal symptoms as well as emotional response of the mo-xibustion group were better（all P〈0.05）.There was statistical significance in the two group about
出处
《中国针灸》
CAS
CSCD
北大核心
2016年第8期815-819,共5页
Chinese Acupuncture & Moxibustion
基金
湖南省教育厅科技处2012年青年课题:12B098
关键词
变应性鼻炎
艾灸
自血疗法
穴位注射
生活质量
白介素-4
干扰素-γ
随机对照试验
allergic rhinitis
moxibustion
autohemotherapy
acupoint injection
quality of life
interleukin-4（IL-4）
interferon-γ（IFN-γ）
randomized controlled trial（RCT）
