摘要
目的评估孕酮（P）和人绒毛膜促性腺激素（β-HCG）在早期妊娠结局预测中的作用。方法经我院伦理委员会批准,于2015年7月-12月期间,就诊我院门诊并随机选取132例有停经史患者作为本研究病例,99例正常妊娠组和33例异常妊娠组。采取静脉血,化学免疫发光法检测P和β-HCG。采用t检验和χ^2检验分析数据。结果正常妊娠组和异常妊娠组P和β-HCG变化趋势比较,差异有统计学意义（P〈0.05）。结论在早期妊娠期,测定P和β-HCG可以预测妊娠结局。当P≥19.2ng/ml,可以认为正常妊娠;当P≤4.58ng/ml,可以认为异常妊娠,如果4.58ng/ml≤P≤19.2ng/ml时,当两次检测β-HCG（间隔48h）,且数值翻倍,同时超声提示可见胎心搏动时,则认为正常妊娠,反之,则认为异常妊娠,明确诊断则需要结合超声检查。
Objective To evaluate the efficacy of Progesterone（ P ）and Human ehorionic gonadotropin（β-HCG ）on predicting the early pregnancy outcome. Methods After our hospital IRB approved,A total of 132 cases between Janu- ary to December 2015 were reviewed, and they were diagnosed with missed their menstrual period were enrolled for this study;Group I （99 patients） normal pregnancy group;and Group II （33 patients） abnormal pregnancy group. The serum values of P and β-HCG were checked at different time point by the chemiluminescence immunoassay. The data was analyzed by t test or χ^2 test. Results There were statistical significance in the difference of normal pregnancy group and abnormal pregnancy group at the value of P and the tendency changes of β-HCG （P〈0.05）. Conclusion In the early pregnancy time period, the values of P and β-HCG could be used to predict the pregnant outcome. If P≥19.2 ng/ml,it can be considered normal pregnancy; if P≤4.58 ng/ml,it can be considered abnormal pregnancy; if 4.58 ng/ml≤P≤19.2 ng/ml,the ffHCG was checked at every 48hrs. If the values of ffHCG were double than the previous one, along with positive fetal heart beat by uterine ultra sound, they were considered normal pregnancy, on the other hand , they can be thought abnormal pregnancy; and uterine ultra- sound will be needed to confirm whether normal or abnormal pregnancy.
出处
《中国实验诊断学》
2016年第6期970-971,共2页
Chinese Journal of Laboratory Diagnosis
关键词
孕酮
人绒毛膜促性腺激素
早期妊娠
progesterone
human chorionic gonadotropin
early pregnancy
