摘要
近年来,肝癌的发病率呈上升趋势,进一步了解肝癌发生的相关分子机制,了解其致病机理,对保障健康有重要意义。斑马鱼是一种重要的模式生物,与人类基因高度保守,其生长速度快,早期胚胎透明,有助于对发育过程实时观测;并且其肝脏细胞的构成、功能、信号通路,甚至是对于损伤的反应都与人类极度相似。在现代生物研究中,斑马鱼作为人类肝病模型得到广泛应用。主要介绍了斑马鱼作为肝癌模型的应用及研究进展,认为斑马鱼肝癌模型构建技术已经较为成熟,随着实验技术的不断发展,其在肝癌研究领域将取得更大的进步。
The incidence rate of liver cancer tends to increase in recent years,and the molecular and pathogenic mechanisms of liver cancer should be further investigated to guarantee health. As an important model organism,zebrafish have highly conserved genes and grow fast.The early embryo of zebrafish is transparent,which helps with the real- time observation of the development process. Zebrafish are similar to humans in the composition,function,and signaling pathways of hepatocytes,as well as response to injury. In modern biological studies,zebrafish have been wildly used as the model of liver diseases. This article summarizes the research advances in the application of zebrafish as the model of liver cancer,and points out that the techniques for establishing the zebrafish model of liver cancer have become mature. With the constant development of experimental techniques,great achievements will be achieved in the field of liver cancer.
出处
《临床肝胆病杂志》
CAS
2016年第7期1425-1428,共4页
Journal of Clinical Hepatology
关键词
肝肿瘤
实验性
斑马鱼
综述
liver neoplasms
experimental
zebrafish
review
