摘要
目的探讨妥布霉素地塞米松滴眼液治疗后部睑缘炎的临床疗效及安全性。方法将2014年1月至2014年12月在咸阳市中心医院眼科门诊接受治疗的后部睑缘炎患者按照随机数字表法分为研究组和对照组,对照组采用妥布霉素滴眼液滴眼治疗,研究组则采用妥布霉素地塞米松滴眼液阶梯疗法治疗,观察两组治疗10、20、40 d的临床症状和体征评分,比较之后40 d的临床疗效及不良反应发生情况。结果研究组和对照组患者在治疗前症状及体征计分比较无明显差异(t=0.36,P>0.05)。在治疗后10、20及40 d,两组患者在不同时间段的症状及体征计分均有不同程度的下降,而且与治疗前比较,差异均显著(F=39.65、4.50,P<0.05)。这表明两组患者治疗后的临床症状及体征均较本组治疗前有明显改善,其中研究组的改善程度尤其突出,且研究组患者的症状及体征计分均较对照组明显下降,且差异具有统计学意义(t=2.18、4.38、6.68,P<0.05)。在治疗40 d后,研究组患者的临床治疗总有效率明显高于对照组,且差异具有统计学意义(χ2=7.59,P<0.05)。两组患者在治疗10、20、40 d后的眼内压水平与治疗前比较均无明显差异(F=2.06、0.13,P>0.05);对两组之间进行比较发现,研究组在治疗前及治疗10、20、40 d后的眼内压水平与对照组比较均无明显差异(t=0.12、0.36、0.45、0.52,P>0.05)。结论妥布霉素地塞米松滴眼液在治疗后部睑缘炎过程中可以有效改善患者的临床症状及体征,而且采用阶梯式短期滴眼治疗可以有效规避地塞米松易致眼压升高的风险,值得临床推广应用。
Objective To study the clinical efficacy and the safety of tobramycin dexamethasone eye drops in treating posterior blepharitis.Methods This study chose posterior blepharitis patients from January 2014 to December 2014 in ophthalmology clinical department of Xianyang central hospital.According to the digital table method,patients were randomly divided into research group and control group.Research group was given tobramycin dexamethasone eye drops ladder therapy,and control group received tobramycin eye drops treatment.Clinical signs and symptom score of the two groups were observed on 10,20,40 d after treatment,the clinical curative effect and adverse reactions were also compared after the 40 d of operation.Results Clinical signs and symptom score of the two groups have no significant difference（t=0.36,P〉0.36） before treatment.The scores of the two groups declined during different period in 10,20 and 40 d after treatment,and the difference is significant when compared with the scores before treatment（F =39.65,4.50,P〈0.05）.This shows that the two groups＇ clinical symptoms and signs scores after treatment significantly improved than before.Statistical analysis finds that research grooup＇s symptoms and signs score are significantly lower than control group,with statistically significant difference（t=2.18,4.38,6.68,P〈0.05）.After treatment of 40 d,the clinical total effective rate of research group is obviously higher than that of control group,and the difference is statistically significant（ χ^2=7.59,P〈0.05）.After treatment of 10,20,40 d,intraocular pressure level of the two groups has no obvious difference compared with before treatment（F=2.06,0.13,P〉0.05）; comparison between the two groups finds that intraocular pressure level has no significant difference before the treatment and 10,20,40 d after the treatment（t =0.12,0.36,0.45,0.36,P〉0.05）.Conclusion Tobramycin dexamethasone eye drops in the treatment of blepharitis can effectively improve the patient＇s clinical symptom
出处
《临床医学研究与实践》
2016年第12期9-11,共3页
Clinical Research and Practice
关键词
妥布霉素地塞米松滴眼液
后部睑缘炎
疗效
安全性
tobramycin dexamethasone eye drops
the rear blepharitis
curative effect
security
