摘要
目的:探究ZEB1的表达与三阴性乳腺癌(TNBC)临床病理及预后的关系。方法:收集我院75例三阴性乳腺癌患者的肿瘤组织标本及临床病理资料,免疫组化法分析肿瘤组织中ZEB1的表达情况以及其表达与临床病理特征及预后之间的关系。结果:免疫组化结果显示75例标本中ZEB1阳性表达14例,阳性率18.7%。ZEB1的表达与患者的年龄、肿瘤分期、组织学分级、是否有淋巴结转移以及p53的表达情况无关(P>0.05),与组织学类型及Ki-67增殖指数有关(P<0.05)。Kaplan-Meier生存曲线分析患者的DFS显示,ZEB1的表达与TNBC患者的预后成负相关(P<0.05)。结论:在TNBC中,ZEB1的表达与肿瘤的组织类型、浸润、转移及患者预后密切相关,其表达可以作为一种潜在的临床病理指标来评价TNBC的恶性程度与预后。
Objective：To explore the relationship between ZEB1 expression and clinical pathology and prognosis of triple -negative breast cancer（TNBC）.Methods：Collecting tissue samples from 75 cases of patients with triple -negative breast cancer and the clinicopathologic data.Immunohistochemistry was used to analyze the expression of ZEB1 in tumor tissue and relationship between their expression and clinicopathological features and prognosis.Re-sults：Immunohistochemistry showed that 14 in 75 cases of specimens ZEB1 were positive expression,and the positive rate was 18.7%.ZEB1 expression was irrelevant to patients＆#39;age,tumor stage,histological grade,lymph node metasta-sis and the expression of p53（P〉0.05）,and related to histological type and Ki -67 proliferation index （P〈0.05）. Kaplan -Meier survival curves analyzed the DFS of patients,which displayed that ZEB1 expression was negatively correlated to prognosis in patients with TNBC （P〈0.05）.Conclusion：In TNBC,ZEB1 expression was closely asso-ciated with tumor tissue type,invasion,metastasis and prognosis.The expression can be used as a potential clinico-pathological indicator to assess the degree of malignancy and prognosis of TNBC.
出处
《现代肿瘤医学》
CAS
2016年第13期2067-2069,共3页
Journal of Modern Oncology
基金
陕西省自然科学基础研究计划项目(编号:2014JM4019)
关键词
三阴性乳腺癌
ZEB1
免疫组化
病理
triple -negative breast cancer
immunohistochemistry
pathology
