摘要
目的：探讨含梭形/巨细胞肺癌（lung carcinoma with spindle/giant cells,LCSG）的临床病理特征和预后。方法：回顾性总结分析1985年9月至2009年7月就诊的28例LCSG的临床和组织病理学资料。利用生存曲线进行生存分析,Cox风险比例模型分析影响预后的因素。结果：LCSG患者男女比例为11∶3,年龄33~73岁,中位年龄60岁;p TNM分期：Ⅰ期8例,Ⅱ期7例,Ⅲ期11例,Ⅳ期2例;病理类型：含梭形细胞癌11例,其中单纯梭形细胞癌2例,梭形细胞癌伴鳞癌5例、伴腺癌3例和伴腺鳞癌及大细胞癌1例;含巨细胞癌17例,其中单纯巨细胞癌13例,巨细胞癌伴鳞癌1例、伴腺癌3例。单纯肉瘤样细胞型患者的中位生存期较混合有上皮样细胞型者长（22.8个月vs 8.0个月,P=0.022）。单因素分析显示,年龄（P=0.002）、肿瘤大小（P=0.005）、组织学类型（P=0.001）、p TNM分期（P=0.015）、T分期（P=0.008）、淋巴结转移（P=0.013）和M分期（P=0.000）是影响LCSG患者预后的因素。结论：混合有上皮样细胞型的LCSG预后较单纯肉瘤样细胞型差;年龄、肿瘤大小和组织学类型是影响LCSG患者预后的因素。
Objective：To investigate the clinicopathologic characteristics and prognosis of lung carcinoma with spindle /giant cells（LCSG）.Methods：From september 1985 to July 2009,clinicopathologic records of 28 patients with LCSG were reviewed and analyzed.Kaplan -Meier method was used for survival analysis.Cox proportional haz-ards model was used for prognostic analysis.Results：In 28 patients there were 22 male and 6 female with median age of 60（33 ~73）years old,8 in stageⅠ,7 stage Ⅱ,11 stage Ⅲ and 2 stage Ⅳ in pathologic TNMstage.Of the 11 ca-ses of lung carcinoma with spindle cells,2 were exclusive spindle cell carcinoma,9 were mixed with epithelial compo-nents,such as squamous cell carcinoma in 5 cases,adenocarcinoma in 3 cases,adenosquamous and large cell carcino-ma in 1 case.Of the 17 cases of lung carcinoma with giant cells,13 were exclusive giant cell carcinoma,4 were mixed with epithelial components,such as squamous cell carcinoma in 1 case and adenocarcinoma in 3 cases.The median survival time was shorter in mixed epithelioid cell type than single sarcomatous carcinoma（8.0 months vs 22.8 months,P =0.022）.Age（P =0.002）,tumor size （P =0 .005 ）,histologic type （P =0 .00 1 ）,pTNM stage （P=0.015）,T stage（P =0.008）,N stage（P =0.013）and M stage（P =0.000）were prognostic factors of LCSG by univariate analysis.Conclusion：LCSG with mixed epithelioid cells had worse prognosis than with single sarcomatous cells.Age,tumor size and histologic type were prognostic factors of LCSG.
出处
《现代肿瘤医学》
CAS
2016年第13期2059-2063,共5页
Journal of Modern Oncology
关键词
肺肿瘤
梭形细胞
巨细胞
肉瘤样癌
多形性癌
病理
lung neoplasm
spindle cells
giant cells
sarcomatous neoplasm
pleomorphic neoplasm
pathology
