摘要
目的研究伴有梭形和/或巨细胞肺癌的病理学特征。方法采用光镜及免疫组织化学方法,研究20例伴有梭形和/或巨细胞肺癌患者的病理学资料。结果20例患者中,15例为多形性癌,其中10例伴腺癌成分,3例伴大细胞癌成分,1例伴鳞癌成分,1例伴巨细胞癌成分;4例为梭形细胞癌;1例为巨细胞癌。免疫组织化学结果显示,19例患者梭形细胞和/或巨细胞成分AE1/AE3阳性,20例患者Vimentin均为阳性,10例患者P53阳性,20例患者甲状腺转录因子1(TTF-1)均为阴性。结论伴有梭形和/或巨细胞的肺癌是一组分化差、含有梭形细胞、巨细胞和/或两种细胞混合成分的非小细胞癌,病理组织学及免疫组织化学AE1/AE3、Vimentin有助于确定其诊断。
Objective To study the pathologic features of pulmonary carcinomas with spindle and/or giant cells. Methods Twenty cases of pulmonary carcinomas with spindle and/or giant cells were studied by using lightmicroscopy and immunohistochemical staining. Results Of 20 cases, 15 cases were pleomorphic carcinoma ( 10 cases with adenocarcinoma, 3 cases with large cell carcinoma, 1 case with squamous cell carcinoma and 1 case with giant cell carcinoma), 4 cases were spindle cell carcinoma, and 1 case was giant cell carcinoma. Immunohistochemical results showed AE1/AE3 was positive in the spindle and/or giant cell component of 19 cases, Vimentin was positive in the spindle and/or giant cell component of 20 cases, P53 was positive in 10 cases and thyoid transcription factor-1 ( TTF-1 ) was negtive in all cases. Conclusions Pulmonary carcinomas with spindle and/or giant cells is definded as a group of poorly differentiated non-small cell carcinoma that contains a component of spindle and/or giant cells. The diagnosis is based on histopathology and immunohistochemical staining of AE1/AE3 and Vimentin.
出处
《中国医学科学院学报》
CAS
CSCD
北大核心
2006年第3期391-394,i0008-i0009,共6页
Acta Academiae Medicinae Sinicae
关键词
肺
多形性癌
梭形细胞癌
巨细胞癌
临床病理
免疫组织化学
pulmonary
pleomorphic carcinoma
spindle cell carcinoma
giant cell carcinoma
clinicopathology
immunohistoehemistry