摘要
目的:观察三参地萸汤对鼻咽癌放疗患者的增效减毒作用及对生活质量和转移的影响。方法:将120患者根据入院先后顺序按随机数字表法分为对照组和观察组。对照组行调强放射治疗,并配合静脉注射用还原型谷胱甘肽钠。观察组在对照组治疗的基础上加服三参地萸汤。两组疗程均至放疗结束后2周。记录急性放射反应情况;化疗前后采用欧洲癌症病人头颈专用量表(EORTC QLQ-H&N35)评价患者生存质量;进行治疗前后实体肿瘤大小评价;检测治疗前后EB病毒DNA(EBV-DNA),血管内皮生长因子(VEGF),骨型碱性磷酸酶(B-ALP)和基质金属蛋白酶-2(MMP-2)。结果:观察组总有效率为83.93%,高于对照组的67.27%(P<0.05);放疗结束时口腔黏膜、耳、唾液腺、咽、食管和喉的急性放射反应评分均低于对照组(P<0.01);QLQ-H&N35量表疼痛等7个症状评分均低于对照组(P<0.01),张口困难等9个单一症状评分均低于对照组(P<0.01);治疗后观察组血清EBV-DNA,B-ALP,MMP-2和VEGF水平均低于对照组(P<0.01)。结论:三参地萸汤辅助放射治疗NPC患者,具有减轻放射性损伤,改善或稳定患者生活质量,提高临床疗效和预防肿瘤转移的作用。
Objective： To observe the synergy and attenuation effect of Sanshen Diyu decoction as well as its effects on quality of life and lymph node metastasis in patients with radiotherapy for nasopharynx cancer. Method： One hundred and twenty patients were randomly divided into control group and observation group by random number table according to their admission sequence. Patients in control group received intensity modulated radiation therapy and Glutathione Sodium for injection. Based on the treatment of control group, patients in observation group also received Sanshen Diyu decoction. The treatment was lasted until two weeks after radiotherapy in both groups. Acute radiotherapy reactions were recorded. Before and after treatment, quality of life was evaluated by European cancer patient as well as head and neck cancer specific scale （ EORTC QLQ-H＆N35）. Size of solid tumor was evaluated before and after treatment. Levels of epstein-barr virus NDA （EBV-DNA） , vascular endothelial growth factor （VEGF）, bone alkaline phosphates （B-ALP） and matrix metalloproteinase-2 （MMP-2） were detected both before and after treatment. Result： The total effective rate was 83.93% in observation group, higher than 67.27% in control group （P 〈 0.05）. Scores of acute radiotherapy reactions of mouth mucosa, ear, salivary gland, pharynx, esophagus and throat in observation group were lower than those in control group after radiotherapy （P 〈 0.01 ）. Scores of pain and other six symptoms by QLQ-H＆N35 scale and 9 monosymptomatie scores including difficulty in opening mouth in observation group were lower than those in control group （P 〈 0.01）. Levels of EBV-DNA, B-ALP, MMP-2 and VEGF in serum of observation group were lower than those of control group after treatment （P 〈 0.01 ）. Conclusion： As an adjuvant treatment for radiotherapy, Sanshen Diyu decoction can relieve radioactive damages, ameliorate and stabilize quality of life, improve clinical efficacy and prevent tumor metastasis.
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2016年第14期197-201,共5页
Chinese Journal of Experimental Traditional Medical Formulae
基金
湖南省中医药管理中医药科研计划项目(2015074)
关键词
鼻咽癌
放疗
三参地萸汤
生存质量
增效减毒
转移
nasopharynx cancer
radiotherapy
Sanshen Diyu decoction
quality of life
synergy and attenuation
metastasis
