摘要
研究海洋小单孢菌产生的缩肽类化合物rakicidins的体内外抗肿瘤活性。Rakicidin B1、A和B对人结肠癌(HCT-8)细胞有很强的抑制作用,在乏氧培养条件下的抑制作用更强,分别是各自在常氧条件下的15、26和14倍。在移植了HCT-8肿瘤细胞的斑马鱼模型中,B和B1两化合物能显著抑制肿瘤生长。因此,rakicidin B(包括B1)值得进一步作为抗肿瘤药物加以研发。
To investigate the in vitro and in vivo antitumor activities of depsipeptide rakicidins from marine Micromonospora sp. All the compounds were tested for the antitumor activities against Colonic Carcinoma Cell Line HCT-8 cells under hypoxic or normoxic conditions. Rakicidin B1, A and B were approximately 15, 26 and 14-fold more cytotoxic under hypoxic than under normoxic conditions, respectively. Rakicidin B 1 and B exhibited significant antitumor activities against established human tumor HCT-8 xenografts in Zebra fish. Thus, rakicidinB（including B 1） could be further developed into an anti-cancer agent.
出处
《中国抗生素杂志》
CAS
CSCD
北大核心
2016年第7期516-519,523,共5页
Chinese Journal of Antibiotics
基金
福建省化药技术重大研发平台项目(No.2014Y2001)
福建省科技计划项目(No.2015R1009-1,No.2016R1009-1)
福建省海洋高新项目(No.闽海洋高新[2015]32号)
厦门南方海洋研究中心项目(No.厦海渔合[2015]26号)
