摘要
高迁移率族蛋白是一种高度保守的DNA结合蛋白,广泛存在于哺乳动物体内。在核内参与核小体的构建和稳定,调节基因的转录。在核外可介导炎症反应、促进细胞分化及肿瘤生长等。其释放途径主要为主动分泌和被动释放,通过与RAGE、TLR等受体结合,激活相应信号传导途径。近来研究发现,HMGB1与胃癌发生发展、转移、侵袭和靶向治疗密切相关,本文就此作一综述。
High-mobility group box 1（HMGB1）,a highly conserved DNA-binding protein,plays an important role in maintaining nucleosome structures,transcription,inflammation,cell differentiation and tumor growth. It can also be released extracellularly and intracellularly. In addition,HMGB1 also participates in other physiological processes,such as cell proliferation,differentiation and apoptosis by binding with RAGE,TLR and other receptors. HMGB1 is recently discovered to closely relate to genesis,development,metastasis and targeted therapy of gastric carcinoma. This article reviewed and summarized the progress in relating research on screening of HMGB1 and gastric cancer.
出处
《中国卫生标准管理》
2016年第10期166-167,共2页
China Health Standard Management
基金
广西壮族自治区卫生厅科研基金(项目编号:Z2014613)
关键词
胃肿瘤
高迁移率族蛋白
Gastric cancer
High mobility group protein
