摘要高迁移率族蛋白B1（high mobility group box-1,HMGB1）是一类核内非组蛋白,具有多种生物学功能。既往研究发现HMGB1在多种实体性肿瘤如肠癌[1-2]、胰腺癌[3]、乳腺癌[4]、胆囊癌[5]以及造血系统恶性肿瘤[6]中高表达,且与肿瘤的临床分型及肿瘤细胞生长、侵袭、转移密切相关[7-9]。
1Tang D,Kang R,Zeh H J,et al.High mobility group box l and cancer[J].Biochi Biophys Acla,2010,1799(1-2):13l-140. 被引量：1
2Lee H,Park M,Shin N,et al.High mobility box l is phosphoryla Ied by protein kinase C ze Ia and secreted in colon cancer cells[J].Biochem Biophys Res Commun,2012,424(2):321-326. 被引量：1
3Kang R,Tang D,Schapiro N E,et al.The HMGB1/RAGE inflammatory pathway promotes pancreatic tumor growth by regulating mitochondrial bioenergetics[J].Oncogene,2014,33(5):567-577. 被引量：1
4Stoetzer O J,Fersching D M,Sala I C,et al.HMGBl and RAGE in breast cancer patients during neoadjuvant chemotherapy[J].Tumour Biol,2013,34(1):81-90. 被引量：1
5Li M L,Wang X F,Tan Z L,et al.Ethyl pyruvate administralion suppresses growth and invasion of gallbladder cancer cells via down-regulation of HMGBl-rage axis[J].Inl J Immunopathol Phan Tlacol,2012,25(4):955-965. 被引量：1
6Xing J M,Geng F W,Zhi J C,et al.Expression of HMGB-1 and its clinical significance in T-cell Lymphoma[J].Asian Pacific J cancer Prev,2012,13(11):5569-557l. 被引量：1
7Yi L,Yoshitomo C,Kiyohide F,et al.High mobility group box l released from necrotic cells enhances regrowth and metastasis of cancer cells that have survived chemotherapy[J].Eur J Cancer,2013,49(3):741-751. 被引量：1
8Jube S,Rivera Z S.Bianchi M E,et al.Cancer cell secretion of the DAMP protein HMGBl supports progression in malignant mesothelioma[J].Cancer Res,2012,72(13):3290-3301. 被引量：1
9Ohmori H,Lou Y,Kuniyasu H.Non-histone nuclear factor HMGBI as a therapeutic target in colorectal cancer[J].Expert Opin Ther Targets,2011,15(2):183-193. 被引量：1
10Yanai H,Ban T,Wang Z,et al.HMGB proteins function as universal sentinels for nucleic-acid-mediated innate immune responses[J].Nature,2009,462(7269):99-103. 被引量：1
二级参考文献20
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