摘要
目的观察中国国家卒中登记（CNSR）研究中轻型缺血性脑卒中患者急性期神经功能恶化的相关因素。方法以2007年9月～2008年8月CNSR收集的22 216例急性脑血管病患者资料为数据来源,符合入组标准轻型缺血性脑卒中患者2424例,根据临床预后分为恶化组368例,未恶化组2056例,通过单因素和多因素分析寻找与急性期神经功能恶化相关的因素。结果恶化组患者住院时间、糖尿病、新发脑卒中、急性感染、痫性发作、应激性血糖升高、下肢深静脉血栓和肺栓塞发生率较未恶化组明显增高,差异有统计学意义（P〈0.05,P〈0.01）。多因素logistic回归分析显示,入院NIHSS评分（OR=1.08,95%CI：1.03～1.13,P=0.003）、糖尿病（OR=1.73,95%CI：1.26～2.37,P=0.001）、新发脑卒中（OR=9.07,95%CI：5.39～15.26,P=0.000）和急性感染（OR=2.37,95%CI：1.50～3.76,P=0.000）是急性期神经功能恶化的独立预测因素。结论糖尿病、入院NIHSS评分、新发脑卒中、急性感染可能是轻型缺血性脑卒中患者急性期神经功能恶化风险升高的预测因素。
Objective To study the factors associated with acute neurological deterioration in mild ischemic stroke patients.Methods Two thousand four hundred and twenty-four mild ischemic stroke patients were divided into deterioration group（n=368）and deterioration-free group（n=2056）.Factors associated with acute neurological deterioration in mild ischemic stroke patients were analyzed by univariate analysis and multivariate analysis respectively.Results The hospital stay time was significantly longer and the incidence of DM,ischemic stroke,acute infection,stress hyperglycemia,lower extremity thrombosis,pulmonary embolism was significantly higher in deterioration group than in deterioration-free group（P〈0.05,P〈0.01）.Mltivariate logistic regression analysis showed that NIHSS score,DM,ischemic stroke and acute infection were the independent risk factors for acute neurological deterioration in mild ischemic stroke patients（OR=1.08,95%CI：1.03-1.13,P=0.003;OR=1.73,95%CI：1.26-2.37,P=0.001;OR=9.07,95%CI：5.39-15.26,P=0.000;OR=2.37,95%CI：1.50-3.76,P=0.000）.Conclusion NIHSS score,DM,ischemic stroke and acute infection are the independent risk factors for acute neurological deterioration in mild ischemic stroke patients.
出处
《中华老年心脑血管病杂志》
CAS
2016年第7期715-718,共4页
Chinese Journal of Geriatric Heart,Brain and Vessel Diseases
关键词
卒中
糖尿病
脑梗死
感染
stroke
diabetes mellitus
brain infarction
infection
