摘要
禽流感病毒不断重排和变异导致新型流感病毒不断出现,其中有些毒株已经获得了感染哺乳动物的能力,严重危害人类公共卫生安全。近年来,对于禽流感病毒致宿主特异性和致病性的研究取得了一定进展。病毒蛋白某些氨基酸位点的突变就能够改变病毒的宿主特异性,使病毒能够跨宿主传播。而且,病毒的RNA聚合酶、NS1非结构蛋白和几种新发现的病毒蛋白都与病毒的致病性密切相关。论文阐述了禽流感病毒宿主特异性与致病性的分子基础,为禽流感跨物种传播机制研究及防控工作提供参考。
Because of the reassortment and mutant, many new avi and several strains have gained the ability to infect mammals,w safety.In recent years,the studies of host specificity and pathoge progress.Mutation of certain amino acids of virus proteins will b an influenza viruses emerged in these years hich posed great harm to public health and nicity of avian influenza viruses made great e able to change host specificity and enable viruses to spread across different hosts.Moreover, the viral RNA polymerase proteins, NS1 non-structural protein and several newly discovered virus proteins are closely related to virus pathogenicity.This paper de- scribed the molecular basis of host specificity and pathogenicity of avian influenza viruses, which provided an important theoretical basis for cross-species mechanism study and prevention and control of the influen- za viruses.
出处
《动物医学进展》
北大核心
2016年第7期102-105,共4页
Progress In Veterinary Medicine
基金
国家自然科学基金项目(31472206)
关键词
禽流感病毒
宿主特异性
致病性
病毒分子基础
Avian influenza virus
host specificity~ pathogenicity~ molecular basis
