摘要
实验采用交联聚维酮固化厚朴酚磷脂复合物,考察固化对厚朴酚磷脂复合物流动性、溶出度和口服生物利用度的影响。DSC,IR,SEM等物相表征结果表明,厚朴酚以无定形态存在于固化物中;流动性试验结果表明,固化粉末流动性优于其磷脂复合物;溶出度实验结果表明固化粉末能够显著促进厚朴酚的溶出;口服生物利用度实验中,固化粉末较厚朴酚磷脂复合物有更高的生物利用度。交联聚维酮固化厚朴酚磷脂复合物的制备方法较为简单,不仅能提高磷脂复合物流动性和溶出度,还增加了厚朴酚的口服生物利用度。
In this study,magnolol phospholipid complex（ MPC） was prepared and solidified with polyvingypyrrolidone（ PVPP）.The influence of PVPP on MPC＇s flowability,dissolution and oral bioavailability was investigated. The results of phase characterization using differential scanning calorimetry（ DSC）,infrared spectroscopy（ IR）,and scanning electron microscopy（ SEM） showed that magnolol existed in solidified powder and MPC in an amorphous state. In flowability and dissolution experiments,solidified powder showed significant superiority. At the same time,it showed a higher oral bioavailability compared with MPC,with AUC_（0-∞）of 73. 47 μg·h·m L^（-1） vs. 63. 48 μg·h·m L^（-1）. This process for solidifying powder with PVPP is simple and convenient.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2016年第12期2250-2254,共5页
China Journal of Chinese Materia Medica
基金
江苏省"333工程"科研项目(BRA2015494)
江苏省"六大人才高峰"高层次人才培养对象科研项目(2015-YY-011)
