摘要
目的制备避蚊胺缓释霜剂,并研究其体外经皮渗透情况。方法用正交筛选法优化避蚊胺缓释霜剂的处方,采用HPLC法测定避蚊胺的含量。利用Franz扩散池,进行体外经皮渗透试验。结果HPLC测定避蚊胺含量的回收率为101.6%,RSD=1.05%。避蚊胺缓释霜剂的体外渗透系数为0.0157 mg.cm-.2h-1,8 h累积渗透量为0.13 mg.cm-2。结论避蚊胺缓释霜剂中避蚊胺的体外经皮渗透明显减慢,累积渗透量大大减少。
OBJECTIVE To prepare N,N- diethyl - m - toluamide（DET） sustained release cream, and study on its percutaneous permeability in vitro. METHODS DET sustained release cream was screened and optimized by orthogonal - designed method. DET was determined by HPLC method. The percutaneous tests were carried out in vitro by using Franz diffusion cells. RESULTS The average recovery and RSD of DET were 101.6% and 1.05%, respectively. The permeability coefficient and cumulative permeation quantity（8 h） of DET sustained release cream were 0. 0157 mg.cm^-2·h^-1 and 0.13 mg·cm^-2, respectively. CONCLUSION The permeation rate and permeation quantity of DET from DET sustained release cream are decreased obviously.
出处
《华西药学杂志》
CAS
CSCD
北大核心
2007年第2期174-176,共3页
West China Journal of Pharmaceutical Sciences
