摘要
目的 分析早期肺原发黏膜相关淋巴组织（MALT）淋巴瘤的临床特征、治疗方式和预后因素。方法 回顾分析2001—2013年32例早期肺MALT淋巴瘤的临床资料、疗效及生存情况。中位年龄56岁,ⅠE期23例、ⅡE期9例;边缘区B细胞淋巴瘤预后指数（MZLPI）评分0分23例、1分9例。9例接受放疗,8例接受单纯手术,3例手术＋化疗,12例单纯化疗。Kaplan-Meier法计算OS、PFS,Logrank法检验和单因素分析。结果 5年样本数22例。5年OS率为85%,5年PFS率为73%。放疗总缓解9/9,其中CR为6/9,PR为3/9。单因素分析显示未放疗为PFS的影响因素,放疗与未放疗患者5年PFS分别为100%和63%（P=0.029）,5年OS分别为100%和79%（P=0.129）。年龄〉60岁、ECOG评分2分及MZLPI评分1分为PFS及OS的影响因素（P=0.041、0.018、0.044及P=0.001、0.001、0.003）。结论 早期肺MALT淋巴瘤的预后因素包括年龄、ECOG及MZLPI评分。予以受累野低剂量（24~30 Gy）放疗能提高LC率进而延长生存。
Objective To analyze the clinical features, treatment methods, and prognostic factors for early primary pulmonary mucosa-associated lymphoid tissue （MALT） lymphoma. Methods A retrospective analysis was performed on the clinical data, treatment outcomes, and survival of 32 patients with early pulmonary MALT lymphoma from March 2001 to September 2013. The median age of those patients was 56 years. Twenty-three patients had stage ⅠE disease and nine had stage ⅡE disease. According to the marginal zone B-cell lymphoma prognostic index （MZLPI）, twenty-three patients were scored as 0 and nine as 1. Nine patients received radiotherapy, eight patients underwent surgery alone, three patients underwent surgery plus chemotherapy, and twelve patients received chemotherapy alone. The Kaplan-Meier method was adapted for calculating the OS,PFS and the log-rank test was used for survival difference analysis and univariate prognostic analysis. Results The 5-year sample size was 22. The 5-year overall survival （OS） and progression-free survival （PFS） rates were 84.5% and 73.2%, respectively. Radiotherapy yielded an overall response rate of 100%, including a complete response rate of 66.7% and a partial response rate of 33.3%. The univariate analysis showed that non-radiotherapy treatment was a prognostic factor for poor PFS. The patients treated with radiotherapy had significantly higher 5-year PFS rates than those treated without radiotherapy （100% vs. 63.0%,P=0.029）, while there was no significant difference in 5-year OS rate between these two groups （100% vs. 78.8%,P=0.129）. Age older than 60 years, an ECOG score of 2, and an MZLPI score of 1 were prognostic factors for poor PFS （P=0.041, 0.018, and 0.044） and OS （P=0.001, 0.001, and 0.003）. Conclusions The prognostic factors for early pulmonary MALT lymphoma include age, ECOG score, and MZLPI score. Low-dose involved-field radiotherapy （24–30 Gy） can improve local control and survival.
出处
《中华放射肿瘤学杂志》
CSCD
北大核心
2016年第7期713-717,共5页
Chinese Journal of Radiation Oncology
关键词
淋巴瘤
黏膜相关淋巴组织
肋放射疗法
预后
Lymphoma, mucosa-associated lymphoid tissue,lung/radiotherapy
Prognosis
