摘要
目的分析肺原发性黏膜相关淋巴组织淋巴瘤的临床特征和预后。方法回顾分析1999—2012年间14例肺原发性黏膜相关淋巴组织淋巴瘤患者临床资料，其中ⅠE期8例、ⅡE期5例、ⅢE期1例。4例单纯手术治疗，5例术后放疗或化疗，3例化放疗，2例单纯化疗。结果中位年龄为55岁，男女之比为1：1．33。中位随访时间为48．3个月。全组患者均存活，3例患者出现治疗失败。全组患者2、4年无进展生存率分别为91％和69％。治疗失败发生在疗后25～37个月，失败部位为双肺、纵隔淋巴结、右肺和脑膜。结论肺原发黏膜相关淋巴组织淋巴瘤为惰性淋巴瘤，预后良好；临床上可根据患者病变范围和身体状况选择适当治疗。
Objective To analyze the clinical features and prognosis of patients with primary pulmonary mucosa-associated lymphoid tissue （MALT） lymphoma. Methods A retrospective analysis was performed on the clinical data of 14 patients with primary pulmonary MALT lymphoma between 1999 and 2012. Eight patients had Ann Arbor stage Ⅰ E disease, 5 had stage Ⅱ E disease, and 1 had stage Ⅲ E disease. Overall, patients were treated with surgery alone （ n = 4 ）, surgery followed by radiotherapy or chemotherapy （ n = 5 ）, chemotherapy plus radiotherapy （n = 3 ）, or chemotherapy alone （n = 2）. Results The median age at diagnosis was 55 years. The male-to-female ratio was1： 1.33. With a median follow-up of 48.3 months, no patient died during follow-up, but 3 patients had recurrence in the lungs, mediastinal lymph nodes, and right lung and meninges at 24. 5, 28.5, and 36. 5 months, respectively, after treatment. The 2- and 4-year progression-free survival rates were 91% and 69%, respectively. Conclusions Primary pulmonary MALT lymphoma is indolent, and most patients show a good response to treatment. Clinical treatment should be selected according to the lesion and patient~ condition.
出处
《中华放射肿瘤学杂志》
CSCD
北大核心
2014年第1期14-16,共3页
Chinese Journal of Radiation Oncology
关键词
淋巴瘤
肺原发性黏膜相关淋巴组织
治疗
临床特征
预后
Lymphoma, puhnonary mucosa-associated lymphoid tissue/treatment
Clinical features
Prognosisi
